Auto Transplantation of Wisdom Teeth

August 9, 2024 updated by: Cleveland Dental Institute

Auto Transplantation of Wisdom Teeth With or Without Platelet Rich Fibrin for Replacement of Non-Restorable Posterior Teeth.

Autotransplantation emerges as a viable alternative to tooth extraction and prosthetic restoration when conventional endodontic treatments are unfeasible or contraindicated. The success of autotransplantation is influenced by diverse factors, including root development stage, tooth morphology, surgical technique, extraoral duration, recipient socket shape, recipient bed vascularity, and periodontal ligament cell vitality. Preserving periodontal ligament quality and achieving tissue adaptation are pivotal for successful tooth transplantation. Successful donor tooth replacement is influenced by variables like fitting attempts, alveolus-root distance, extra-alveolar time, surgical skill, and extraction trauma intensity.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • United States
    • Ohio
      • Cleveland, Ohio, United States, 44128
        • Recruiting
        • Cleveland Dental Institute
        • Contact:
          • Waleed Elmallah, DDS
          • Phone Number: 216-727-0234
        • Principal Investigator:
          • Luis M De la Rosa, DDS
        • Principal Investigator:
          • Nelza Baladi, DDS
        • Principal Investigator:
          • Waleed Elmallah, DDS
        • Principal Investigator:
          • Mustafa Khallaf, DDS
        • Principal Investigator:
          • Ahmed Hashem, DDS

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • male and female
  • aged between 20 and 50 years
  • devoid of systemic ailments
  • complying with the study procedures
  • holding an Anesthesiologists classification of 1 or 2
  • possessing mandibular or maxillary immature wisdom teeth

Exclusion Criteria:

  • systemic diseases that might impede the healing process
  • Patients with pacemakers
  • Individuals harboring allergies to medications or antibiotics
  • active smokers
  • patients afflicted with periodontal diseases

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Autotransplantation with PRF
Procedure: Autotransplantation with PRF
Autotransplantation of Wisdom teeth to the extracted socket of removed broken down posterior teeth with the application of PRF
Active Comparator: Autotrasplantation only
Procedure: Autotransplatation Only
Autotransplantation of Wisdom teeth to the extracted socket of removed broken down posterior teeth.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Radiographic success
Time Frame: one year
The success of auto-transplanted immature third molars with and without Platelet-Rich Fibrin will be assessed over a year period.
one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cleveland Dental Institute

Investigators

  • Study Chair: Waleed Elmallah, DDS, Cleveland Dental
  • Study Director: Ahmed Hashem, DDS, Cleveland Dental

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2024

Primary Completion (Estimated)

October 31, 2024

Study Completion (Estimated)

March 31, 2025

Study Registration Dates

First Submitted

July 29, 2024

First Submitted That Met QC Criteria

August 9, 2024

First Posted (Actual)

August 14, 2024

Study Record Updates

Last Update Posted (Actual)

August 14, 2024

Last Update Submitted That Met QC Criteria

August 9, 2024

Last Verified

July 1, 2024

More Information

Terms related to this study

Other Study ID Numbers

  • CDIOS00011

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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