Investigation of Validity and Reliability of the Minnesota Manual Dexterity Test in Patients With Multiple Sclerosis

March 17, 2025 updated by: Kader Eldemir, Gazi University

Many assessment tools have been developed and used to evaluate upper extremity functions in multiple sclerosis (MS) patients. While each test has its strengths and weaknesses, the most significant limitation of these tests is that only a limited number assess both hands simultaneously. On the other hand, most daily life activities require the coordinated use of both hands. In MS patients, bilateral impairments in hand functions can also be observed. Therefore, there is a need for bilateral assessment tools.

Unlike many other assessment tools, the Minnesota Manual Dexterity Test (MMDT) allows for simultaneous evaluation of both hands. In addition to manual dexterity, it also assesses hand-eye coordination and gross motor skills. The MMDT consists of five subtests: placing, turning, displacing, single-hand turning and placing, and two-hand turning and placing. The validity of the MMDT has also been examined in MS patients.

Our study aims to evaluate the reliability and validity of the MMDT in MS patients. The cutoff times that best distinguish individuals with MS from healthy individuals will also be examined. The study aims to systematically and thoroughly evaluate the MMDT, establish it as a valid and reliable method for MS patients, and provide a new perspective on assessing hand functions.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

At baseline, the MMDT, EDSS, 9-hole peg test (9-HPT), ABILHAND survey, and Jebsen-Taylor Hand Function Test (JTHFT) will be applied to the MS group. The MMDT will be repeated seven days after the first application in MS. Healthy controls are going to perform only the MMDT.

Study Type

Observational

Enrollment (Actual)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Sivas, Turkey
        • Sivas Cumhuriyet University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Patients with Multiple Sclerosis who apply to Sivas Cumhuriyet University, Department of Physiotherapy and Rehabilitation will be invited to this study.

Description

Inclusion Criteria:

  • Age at least 18 years,
  • Neurologist-diagnosed Multiple Sclerosis,
  • Expanded Disability Status Scale (EDSS) score between 0-6.5
  • No MS exacerbation within the last 3 months,
  • Use of stable medication in the last 3 months.

Exclusion Criteria:

  • Having any vision, hearing or perception problems that may affect the research results,
  • Having an orthopedic problem that may affect manual skills in the upper extremity,
  • Having a cardiovascular, pulmonary disorder

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Test Group
Patients with Multiple Sclerosis
Other: Manual Dexterity
Individuals who meet the inclusion criteria will be evaluated for manual dexterity using MMDT, 9-HPT, ABILHAND, and JTHFT.
Other: disability level
Individuals who meet the inclusion criteria will be evaluated for disability level using EDSS
Control Group
healthy controls
Other: Manual Dexterity (only MMDT)
Individuals who meet the inclusion criteria will be evaluated for manual dexterity using MMDT on a predetermined day.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Minnesota Manual Dexterity Test
Time Frame: baseline (on the predetermined assessment day)
The Minnesota Manual Dexterity Test (MMDT) is a performance test designed to evaluate hand functions and hand-eye coordination both unilaterally and bilaterally, higher scores mean a worse outcome.
baseline (on the predetermined assessment day)
Minnesota Manual Dexterity Test-second
Time Frame: the second assessment will be conducted after the seven days
The Minnesota Manual Dexterity Test (MMDT) is a performance test designed to evaluate hand functions and hand-eye coordination both unilaterally and bilaterally, higher scores mean a worse outcome.
the second assessment will be conducted after the seven days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
ABILHAND
Time Frame: baseline (on the predetermined assessment day)
to assess for performance of activity. score range 0-46 point, higher scores mean a better outcome.
baseline (on the predetermined assessment day)
9-Hole Peg Test
Time Frame: baseline (on the predetermined assessment day)
The 9-Hole Peg Test (9-HPT) evaluates hand dexterity based on performance, higher scores mean a worse outcome.
baseline (on the predetermined assessment day)
The Jebsen Hand Function Test
Time Frame: baseline (on the predetermined assessment day)
The Jebsen Hand Function Test (JHFT) is one of the objective and standardized tests that assesses fine motor skills and functional hand use by simulating daily living activities, higher scores mean a worse outcome.
baseline (on the predetermined assessment day)
The Expanded Disability Status Scale
Time Frame: baseline (on the predetermined assessment day)
The Expanded Disability Status Scale (EDSS) is a scale used to determine the degree of disability resulting from multiple sclerosis (MS). It evaluates eight functional domains: pyramidal, cerebellar, brainstem, sensory, bowel/bladder, visual, mental, and other functions.Score range 0-10, higher scores mean a worse outcome.
baseline (on the predetermined assessment day)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Gazi University

Collaborators

Cumhuriyet University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 28, 2024

Primary Completion (Actual)

January 25, 2025

Study Completion (Actual)

January 25, 2025

Study Registration Dates

First Submitted

November 18, 2024

First Submitted That Met QC Criteria

November 24, 2024

First Posted (Actual)

November 26, 2024

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

March 17, 2025

Last Verified

March 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1-MS-minnesota-reliability

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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