Autogenous Tooth Bone Graft Versus Allogeneic Bone Graft Around Dental Implant in Aesthetic Zone

January 16, 2026 updated by: Diab Abdel Gaied Diab Ghanem Mohammed, Tanta University

24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation using bone grafts either autogenous tooth bone graft or allogenic bone graft Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.

• Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation randomized to two groups Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.

• Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous).

preparation of autogenous tooth bone graft Any restorations, caries, cementum, periodontal ligament and pulp tissue will be removed .The tooth will be grinded using dental bone mill and bone crusher Tooth particles will be sieved to particles size 300 to 1200 microns. The sorted particles will be immersed in 70 % ethanol and 5% Peracetic acid* in a sterile container for 10 minutes to remove any soft tissue remnants, bacteria and smear layer (defatting and sterilization).

Tooth particles will be demineralized using 2% HNO3for 20 minutes to expose the dentine organic matrix.

The bacteria-free particulate dentin will be washed with phosphate buffered saline‡ twice for 5 minutes to restore the PH balance to 7.4. In the same setting, surgical procedure after atraumatic extraction immediate implant willbe inserted according to dimensions taken from CBCT and jumbing gap will be filled with bone graft according to randomization

Study Type

Interventional

Enrollment (Actual)

24

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Tanta, Egypt, 3111
        • Faculty of Dentistry

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

Patients with non restorable maxillary anterior teeth need to be extracted.

  • Thin labial plate of bone of the tooth to be extracted.
  • Patients age above 20years old.
  • Good oral hygiene.
  • No signs of acute infection or inflammation

Exclusion Criteria:

  • Prior radiation therapy.
  • Soft and hard tissue pathology at the operation site.
  • Any relevant systemic disease or medication that might compromise bone healing.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Autogenous tooth bone graft group
Twelve patients receiving immediate implant placement with autogenous fresh partially demineralized dentin graft.
Procedure: Allogeneic bone graft with immediate implant placement
Immediate dental implant placement with grafting of the jumping gap using allogeneic bone graft (DFDBA).
Active Comparator: Allogeneic bone graft group (control group)
Patients receiving immediate dental implant placement with allogeneic bone graft (DFDBA) for grafting of the jumping gap.
Procedure: immediate implant with allogenic bone graft
after atraumatic extraction immediate implant will be inserted with allogenic bone graft

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
marginal bone loss
Time Frame: 6 months
6 months
labial bone thickness
Time Frame: 6 months
measuring thickness of labial bone labial to the implant
6 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
bone density around dental implant
Time Frame: 6 months
bone density will be assessed using CBCT buccal to the implant fixtures 6 months after implant installation
6 months
implant secondary stability
Time Frame: 6 months
Implant stability will be assessed at the time of implant insertion and 6 months after the operation. Resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) will be recorded by a transducer attached to the implant by a screw and a frequencyresponse analyzer (Osstell Mentor Device) with the average of 2measurements performed with the probe in 2 perpendiculardirections
6 months
implant success
Time Frame: 6 months
when the following clinical features arise: emerging of the fistula, the particle of the bone graft material flow out from the fistula or mucosal dehiscence, and the chronic inflammation ragarded as failure
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tanta University

Investigators

  • Principal Investigator: diab abdelgaied diab, master, faculty of dentistry Tanta university
  • Principal Investigator: Rafic ramadan bedir, professor, faculty of dentistry Tanta university
  • Principal Investigator: Ibrahim mohammed nowair, professor, faculty of dentistry Tanta university
  • Principal Investigator: Mona samy sheta, lecturer, faculty of dentistry Tanta university

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 25, 2024

Primary Completion (Actual)

October 16, 2025

Study Completion (Actual)

October 16, 2025

Study Registration Dates

First Submitted

December 30, 2024

First Submitted That Met QC Criteria

January 12, 2025

First Posted (Actual)

January 14, 2025

Study Record Updates

Last Update Posted (Actual)

January 20, 2026

Last Update Submitted That Met QC Criteria

January 16, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • diab123

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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