Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone (TUBERO-IMPLANT)

March 4, 2026 updated by: Tran Duy Anh, University of Medicine and Pharmacy at Ho Chi Minh City

Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series

Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement.

This prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Immediate implant placement has become a widely accepted treatment modality in the esthetic zone. However, the presence of buccal bone defects following tooth extraction may negatively affect peri-implant tissue stability and esthetic outcomes. Autogenous bone graft harvested from the maxillary tuberosity has been proposed as a reliable grafting material due to its corticocancellous structure and high osteogenic potential.

This prospective interventional case series aims to evaluate the effectiveness of autogenous maxillary tuberosity graft used in conjunction with immediate implant placement in the esthetic zone. Patients requiring extraction and implant placement in the maxillary esthetic region will be treated with immediate implant placement and augmentation using a two-layer autogenous graft harvested from the maxillary tuberosity, consisting of cortical bone and connective tissue.

Clinical and radiographic outcomes will be assessed during follow-up. Buccal bone thickness will be evaluated using cone-beam computed tomography (CBCT). Facial soft tissue thickness will be measured clinically. Esthetic outcomes will be assessed using the pink esthetic score (PES) following definitive prosthetic restoration.

The results of this study are expected to provide clinical evidence regarding the effectiveness of maxillary tuberosity autogenous grafts for improving peri-implant tissue stability and esthetic outcomes in immediate implant placement.

Study Type

Interventional

Enrollment (Estimated)

15

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Vietnam
    • Ho Chi Minh
      • Ho Chi Minh City, Ho Chi Minh, Vietnam, 700000
        • Recruiting
        • University of Medicine and Pharmacy at Ho Chi Minh City
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Adults aged 18 years or older
  • Patients requiring single implant placement in the maxillary esthetic zone
  • Indication for immediate implant placement following tooth extraction
  • Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft
  • Adequate oral hygiene and ability to maintain postoperative care
  • Willingness to participate in the study and provide informed consent

Exclusion Criteria:

  • Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases
  • History of radiotherapy in the head and neck region
  • Active periodontal disease or untreated oral infection
  • Heavy smoking (more than 10 cigarettes per day)
  • Pregnancy or lactation
  • Severe parafunctional habits
  • Insufficient bone volume preventing implant placement with the planned protocol
  • Patients unable to attend follow-up visits

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Immediate Implant With Maxillary Tuberosity Graft
Patients receiving immediate implant placement in the maxillary esthetic zone combined with autogenous bone graft harvested from the maxillary tuberosity to reconstruct the buccal bone plate.
Procedure: Immediate Implant Placement With Maxillary Tuberosity Autogenous Graft
Immediate implant placement in the maxillary esthetic zone combined with autogenous bone graft harvested from the maxillary tuberosity. The graft is used to reconstruct the buccal bone plate and improve peri-implant tissue stability and esthetic outcomes.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Buccal Bone Thickness
Time Frame: 6 months after implant placement
Buccal bone thickness around the implant measured on cone-beam computed tomography (CBCT) in the mid-facial aspect of the implant site.
6 months after implant placement

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Facial Soft Tissue Thickness
Time Frame: 6 months after implant placement
Facial peri-implant soft tissue thickness measured clinically at the mid-facial aspect of the implant site.
6 months after implant placement

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Pink Esthetic Score (PES)
Time Frame: 6 months after implant placement
Esthetic evaluation of peri-implant soft tissue using the Pink Esthetic Score (PES) assessed after prosthetic restoration.
6 months after implant placement

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Medicine and Pharmacy at Ho Chi Minh City

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2026

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

November 1, 2026

Study Registration Dates

First Submitted

March 4, 2026

First Submitted That Met QC Criteria

March 4, 2026

First Posted (Actual)

March 10, 2026

Study Record Updates

Last Update Posted (Actual)

March 10, 2026

Last Update Submitted That Met QC Criteria

March 4, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MT-BLOCK-GRAFT-IMPLANT

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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