The Investigation of Predicting Mortality and Morbidity in Patients Admitted to Intensive Care Unit With Thoracic Trauma Using Selected Biomarkers and Parameters

This prospective study aimed to predict morbidity and mortality after thoracic trauma in intensive care unit evaluated clinical and biochemical data of 50 intensive care unit patients. The research examined demographic factors such as gender, age, and smoking status, trauma scoring systems like ISS and RTS as well as biomarkers such as Surfactant-d and oxygenation parameters including the ROX index, PaO₂/FiO₂ ratio and FiO₂.

Study Overview

• Status: Completed
• Conditions: Thorax Traumas
• Intervention / Treatment: Diagnostic test: blood sampling

• Study Type: Observational
• Enrollment (Actual): 50

Contacts and Locations

Study Locations

• Turkey
  • Isparta, Turkey, 32260
    • Suleyman Demirel University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients with thoracic trauma admitted to icu

Description

Inclusion Criteria:

• Patients with thoracic trauma between the ages of 18-85
• Patients who have been monitored in intensive care for at least 1 week

Exclusion Criteria:

• Being outside the age range of 18-85
• Pregnant patients
• Patients whose intensive care follow-up lasted less than 1 week
• Patients who do not want to be included in the study
• Patients with a lung malignancy diagnosis before admission

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
thorax trauma patients; thorax trauma patients admitted to icu	Diagnostic test: blood sampling; blood samples obtained for 3 different days, limited to 5cc

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality Prediction Using ROX Index in Thoracic Trauma Patients	To evaluate the predictive ability of the ROX index (unit: cmH₂O/L/s) for mortality in thoracic trauma patients. ROX index values were recorded at 1st, 3rd, and 7th days of hospitalization using standard clinical monitoring and ventilatory support parameters. Trends were analyzed in relation to survival outcomes.	Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission.
Mortality Prediction Using SP-D Levels in Thoracic Trauma Patients	To assess the prognostic value of Surfactant Protein D (SP-D) levels (unit: ng/mL) for mortality prediction in thoracic trauma patients. SP-D levels were measured using an ELISA assay (Elabscience® Human Pulmonary Surfactant-associated Protein-D ELISA Kit) at 1st, 3rd, and 7th days to evaluate trends and correlations with survival outcomes.	Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Predictive Value of APACHE II Score in Mortality	To analyze the effectiveness of the APACHE II score (range: 0-71; higher scores indicate worse outcomes) in predicting mortality in thoracic trauma patients. APACHE II scores were calculated based on clinical and laboratory parameters, including vital signs, blood gas values, and organ dysfunction markers at 1st, 3rd, and 7th days.	Measurements taken on day 1, day 3, and day 7 of hospitalization.
Predictive Value of SOFA Score in Mortality	To evaluate the prognostic accuracy of the Sequential Organ Failure Assessment (SOFA) score (range: 0-24; higher scores indicate worse outcomes) in thoracic trauma patients. SOFA scores were determined based on respiratory, cardiovascular, hepatic, coagulation, renal, and neurological functions at 1st, 3rd, and 7th days.	Measurements taken on day 1, day 3, and day 7 of hospitalization.
Predictive Value of TRISS Score in Mortality	To examine the relationship between Trauma and Injury Severity Score (TRISS) (range: 0-100%; higher scores indicate better survival probability) and survival outcomes in thoracic trauma patients. TRISS scores were calculated using physiological and anatomical injury severity data at 1st, 3rd, and 7th days.	Measurements taken on day 1, day 3, and day 7 of hospitalization.
Predictive Value of RTS Score in Mortality	To assess the relationship between Revised Trauma Score (RTS) (range: 0-7.84; higher scores indicate better prognosis) and mortality risk in thoracic trauma patients. RTS scores were calculated using Glasgow Coma Scale, systolic blood pressure, and respiratory rate values at 1st, 3rd, and 7th days.	Measurements taken on day 1, day 3, and day 7 of hospitalization.
CRP Levels and Mortality Prediction	To evaluate the association between C-reactive protein (CRP) levels (unit: mg/L) and mortality in thoracic trauma patients.	Measurements taken on day 1, day 3, and day 7 of hospitalization.
Procalcitonin Levels and Mortality Prediction	To analyze the prognostic value of procalcitonin (unit: ng/mL) levels in mortality prediction among thoracic trauma patients.	Measurements taken on day 1, day 3, and day 7 of hospitalization.

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
NEU/LYM Ratio and Mortality Correlation	To investigate the prognostic role of the Neutrophil-to-Lymphocyte Ratio (NEU/LYM) (unit: ratio value) in predicting mortality among thoracic trauma patients. NEU/LYM values were obtained from complete blood count (CBC) results and recorded at 1st, 3rd, and 7th days	Measurements taken on day 1, day 3, and day 7 of hospitalization.
Glasgow Coma Scale (GCS) and Mortality Correlation	Description: To evaluate the predictive value of the Glasgow Coma Scale (GCS) score on mortality and other clinical outcomes in thoracic trauma patients. Score Range: 3-15 (lower scores indicate worse outcomes).	Measurements taken on day 1, day 3, and day 7 of hospitalization.

Collaborators and Investigators

• Sponsor: Suleyman Demirel University
• Investigators: Study Director: pınar karabacak, Suleyman Demirel University

Publications and helpful links

General Publications

• Determann RM, Royakkers AA, Haitsma JJ, Zhang H, Slutsky AS, Ranieri VM, Schultz MJ. Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients. BMC Pulm Med. 2010 Feb 16;10:6. doi: 10.1186/1471-2466-10-6.
• Baker JE, Millar DA, Heh V, Goodman MD, Pritts TA, Janowak CF. Does chest wall Organ Injury Scale (OIS) or Abbreviated Injury Scale (AIS) predict outcomes? An analysis of 16,000 consecutive rib fractures. Surgery. 2020 Jul;168(1):198-204. doi: 10.1016/j.surg.2020.04.032. Epub 2020 May 13.
• Lundin A, Akram SK, Berg L, Goransson KE, Enocson A. Thoracic injuries in trauma patients: epidemiology and its influence on mortality. Scand J Trauma Resusc Emerg Med. 2022 Dec 12;30(1):69. doi: 10.1186/s13049-022-01058-6.

Study record dates

Study Major Dates

• Study Start (Actual): April 15, 2023
• Primary Completion (Actual): March 15, 2024
• Study Completion (Actual): April 15, 2024

Study Registration Dates

• First Submitted: January 3, 2025
• First Submitted That Met QC Criteria: April 8, 2025
• First Posted (Actual): April 16, 2025

Study Record Updates

• Last Update Posted (Actual): April 16, 2025
• Last Update Submitted That Met QC Criteria: April 8, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Keywords: ROX index; thorax trauma; Surfactant-d
• Additional Relevant MeSH Terms: Wounds and Injuries
• Other Study ID Numbers: SENCER-CELIK-001

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No