Oral Health Related Quality of Life of Children With Amelogenesis Imperfecta

Evaluation of the Impact of Anterior Veneers on the Quality of Life of Children With Amelogenesis Imperfecta

This project aims to evaluate the impact of anterior veneer treatment on oral health-related quality of life in children with amelogenesis imperfecta (AI). AI is an inherited disorder that causes structural defects in enamel due to genetic abnormalities, leading to aesthetic, functional, and psychosocial challenges. Enamel defects, particularly in the anterior teeth, negatively affect patients' self-confidence and social interactions. In this study, the short-term aesthetic, functional, and psychosocial effects of veneer restorations applied to children with AI will be assessed.

This research is designed as a single-center, prospective clinical study. The study population will include pediatric patients aged 11-14 years who have been clinically and radiographically diagnosed with AI at our faculty clinic. Participants' oral health-related quality of life will be evaluated before treatment and one month after treatment using the Child Perceptions Questionnaire (CPQ11-14). Psychosocial improvement will be measured using the Rosenberg Self-Esteem Scale and the Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ), while aesthetic satisfaction will be assessed using a Visual Analogue Scale (VAS). In addition, to objectively evaluate the participants' oral hygiene and dental health, the plaque index, gingival index, bleeding on probing index, and DMFT index will be recorded.

The data obtained are expected to demonstrate the positive impact of veneer treatment on the quality of life of children with AI, emphasizing the importance of early aesthetic rehabilitation in pediatric patients. In this respect, the study aims to provide a novel clinical and psychosocial contribution to the existing literature on the management of AI in pediatric dentistry.

Study Overview

• Status: Recruiting
• Conditions: Amelogenesis Imperfecta
• Intervention / Treatment: Procedure: Veneers

• Study Type: Observational
• Enrollment (Estimated): 20

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Istanbul, Turkey (Türkiye)
    • Recruiting
    • Istanbul University, Faculty of Dentistry, Department of Pedodontics
    • Contact: Yelda Kasımoğlu, Assoc. Prof.; Phone Number: 00905336233978; Email: yelda.kasimoglu@istanbul.edu.tr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Children with amelogenesis imperfecta

Description

Inclusion Criteria:

• Systemically healthy,
• Aged between 11 and 14,
• Diagnosed with Amelogenesis Imperfecta,
• Need for anterior veneers,
• Both female and male volunteers

Exclusion Criteria:

• Those with systemic diseases,
• Those with a history of allergies,
• Those not diagnosed with Amelogenesis Imperfecta,
• Those without an indication for veneers,
• Those lacking adequate cooperation skills,
• Patients younger than 11 or older than 14 years will not be included in the study.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Case; Children with amelogenesis imperfecta	Procedure: Veneers; Anterior veneer treatment
Control; Children with healthy teeth and periodontium

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
oral health related quality of life	CPQ11-14	1 month and 6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
hypersensitivity	Wong-Baker scale	3 months
oral hygiene	plaque index	3 months
gingival health	gingival index	3 months
self esteem	Rosenberg Self-Esteem Scale	1 month and 6 months
psychosocial impact of dental aesthetics	PIDAQ	1 month and 6 months
gingival bleeding	bleeding on probing	1 month and 6 months
caries status	DMFT	1 month and 6 months

Collaborators and Investigators

• Sponsor: Istanbul University

Study record dates

Study Major Dates

• Study Start (Actual): November 24, 2025
• Primary Completion (Estimated): July 23, 2026
• Study Completion (Estimated): August 5, 2026

Study Registration Dates

• First Submitted: November 19, 2025
• First Submitted That Met QC Criteria: November 19, 2025
• First Posted (Actual): November 26, 2025

Study Record Updates

• Last Update Posted (Actual): May 12, 2026
• Last Update Submitted That Met QC Criteria: May 7, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: quality of life; CPQ11-14
• Additional Relevant MeSH Terms: Developmental Defects of Enamel; Stomatognathic Diseases; Tooth Diseases; Stomatognathic System Abnormalities; Congenital Abnormalities; Tooth Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Amelogenesis Imperfecta; Equipment and Supplies; Prostheses and Implants; Dentistry; Dental Prosthesis; Prosthodontics; Dental Veneers
• Other Study ID Numbers: 2025/129

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No