Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

November 25, 2025 updated by: Muhammad Aamir Latif

Functional Outcomes of Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

In animal studies, platelet-rich plasma has shown excellent results in accelerating the healing of the anterior cruciate ligament, but studies on human have shown varying clinical outcomes when investigating platelet-rich plasma for its effects on anterior cruciate ligament reconstruction. The findings of this study could provide important insights about the possible role of platelet-rich plasma in arthroscopic anterior cruciate ligament reconstruction by hamstring graft. to enhance early graft healing and reduce early complications, though its long-term effectiveness remains inconsistent. Studies suggest PRP may improve short-to-medium term outcomes like reduced pain and enhanced knee function,

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
    • Punjab Province
      • Lahore, Punjab Province, Pakistan, 54000
        • Lahore General Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Any gender
  • Aged 18-40 years
  • With clinically and radiologically confirmed arthroscopic evidence of ACL injury

Exclusion Criteria:

  • With comprised bilateral ACL tears
  • Lack of fitness due to associated comorbidity
  • Fractures of lower limb bones and/or spine/neurovascular injuries
  • Injuries to other knee ligaments
  • Significant knee joint arthritis
  • Local skin infections

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: ACL reconstruction by hamstring graft with PRP group
Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.
Procedure: ACL reconstruction by hamstring graft with PRP
Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.
Experimental: ACL reconstruction by hamstring graft group
Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.
Procedure: ACL reconstruction by hamstring graft
Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Anterior Drawer's test
Time Frame: 12 weeks
Number of patients having grade-1 on the Anterior Drawer's test
12 weeks
Lachman's test
Time Frame: 12 weeks
Number of patients having grade-1 on the Lysholm knee score
12 weeks
Lysholm knee score
Time Frame: 12 weeks
A higher Lysholm knee score was labeled as effectiveness of the treatment.
12 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Muhammad Aamir Latif

Investigators

  • Principal Investigator: Naveed Ali, FCPS, Lahore General Hospital, Lahore, Pakistan
  • Study Director: Muhammad Hanif, FCPS, Lahore General Hospital, Lahore, Pakistan

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 15, 2022

Primary Completion (Actual)

June 30, 2023

Study Completion (Actual)

June 30, 2023

Study Registration Dates

First Submitted

November 25, 2025

First Submitted That Met QC Criteria

November 25, 2025

First Posted (Actual)

December 8, 2025

Study Record Updates

Last Update Posted (Actual)

December 8, 2025

Last Update Submitted That Met QC Criteria

November 25, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • DR-NAVEED-LGH

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Data can be shared on a reasonable request.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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