Advanced PRF vs PRF for Gap Filling in Immediate Implants (A-PRF vs PRF)

December 20, 2025 updated by: Eman Magdy Ahmed, Beni-Suef University

Comparison of Advanced Platelet Rich Fibrin Versus Platelet Rich Fibrin as a Gap Filling Material in Immediate Implant Placement

Study type: Clinical Trial

Goal:

The goal of this clinical trial is to learn if Advanced Platelet-Rich Fibrin (A-PRF) versus traditional Platelet-Rich Fibrin (PRF) can improve bone healing and soft tissue outcomes in patients undergoing immediate dental implant placement.

Main questions it aims to answer:

Does A-PRF provide greater buccal bone preservation compared to PRF after immediate implant placement?

Does A-PRF improve soft tissue healing and reduce postoperative complications compared to PRF?

Comparison group:

Researchers will compare A-PRF to PRF as a gap-filling material in immediate implants to see if A-PRF results in better bone and soft tissue outcomes.

Participants will:

Undergo tooth extraction followed by immediate implant placement

Receive either A-PRF or PRF as the gap-filling material in the implant site

Have CBCT scans at baseline and 6 months to measure bone thickness

Have clinical assessments of soft tissue healing and implant stability

Attend follow-up visits at 1 week, 1 month, 3 months, and 6 months post-surgery

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

16

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Al Mansurah, Egypt, 35516
        • Delta University for Science and Technology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • The selected patients has a badly decayed mandibular posterior teeth which are indicated for extraction due to dental causes (periapical abscess, trauma or caries) not periodontal as diagnosed by periapical x-ray.
  • Healthy patients who are classified according to the American Society of Anesthesiologists (ASA)(2022) physical status classification as class I.
  • Patient age ≥ 20 years old.
  • Surgical site with sufficient for implant placement.
  • Sufficient interocclusal space for prosthesis.
  • Good oral hygiene.
  • Patients have thick biotype.
  • Patients have socket class I.

Exclusion Criteria:

  • Active periodontal diseases and periapical lesions not chronic infections.
  • Patients have parafunctional
  • History of alcohol or drug dependency, psychological factor that might affect the surgical or prosthodontic treatment.
  • Smoking.
  • Pregnant patients.
  • Patients who are not willing to complete the study.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: PRF Group
Participants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with traditional Platelet-Rich Fibrin (PRF) as the gap-filling material.
Procedure: Immediate dental implant and PRF
Arm 2: Platelet-Rich Fibrin (PRF) Participants will have a tooth extracted, the socket cleaned, and traditional PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.
Experimental: A-PRF Group
Participants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with Advanced Platelet-Rich Fibrin (A-PRF) as the gap-filling material.
Procedure: Immediate Dental Implant and A-PRF
Arm 1: Advanced Platelet-Rich Fibrin (A-PRF) Participants will have a tooth extracted, the socket cleaned, and A-PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Clinical evaluation
Time Frame: 6 month
Implant stability will be measured by resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) unit at 6 months post-operative
6 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Beni-Suef University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 25, 2025

Primary Completion (Actual)

November 26, 2025

Study Completion (Estimated)

February 15, 2026

Study Registration Dates

First Submitted

November 30, 2025

First Submitted That Met QC Criteria

December 20, 2025

First Posted (Actual)

January 6, 2026

Study Record Updates

Last Update Posted (Actual)

January 6, 2026

Last Update Submitted That Met QC Criteria

December 20, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • DU:024111959

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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