Evaluation of the Effect of Leucocyte Platelet-Rich Fibrin (L-PRF) Technique Applied in Post-extraction Sockets Before Placement of Dental Implants

January 27, 2026 updated by: Maria Pavli, National and Kapodistrian University of Athens

Aim of study: The application of L-PRF membrane in post-extraction sockets outmatches the use of a) allograft covered with a collagen fleece b) allograft combined with L-PRF membrane c) natural healing, with reference to bone remodeling and regeneration of post-extraction sockets.

Moreover, it will be examined whether the application of L-PRF membrane leads to faster bone maturation and creation of a favorable biological environment for earlier implant placement.

Materials and methods: This study is taking place in Athens University Dental School, in Oral and Maxillofacial Surgery Clinic. All patients participating in the present study received thorough informed consent. All forty patients participating in this study, were subjected in at least one atraumatic and flapless extraction of a single rooted tooth in the maxilla or mandible. Then, the patients were randomly divided in four categories with regards to management of the socket: a) no intervention i.e. Natural healing b) application of L-PRF membrane in the socket c) application of allograft (Phoenix) covered with a collagen fleece d) application of allograft (Phoenix) covered with a L-PRF membrane. Interrupted sutures will be performed for the four extraction socket groups.

Radiographic examination (localized CBCT) was obtained immediately before the extraction, as well as three months post-operatively (localized CBCT) in order to assess the changes in the alveolar ridge dimensions. The next stage of the study refers to the rehabilitation of the edentulous region.

Before each patient was subjected to dental implant placement, a bone biopsy was obtained.

Therefore, all the biopsy specimens obtained went through histological evaluation in order to assess qualitative and quantitative features.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Greece
      • Athens, Greece, 11527
        • Athens Univeristy Dental School

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  1. Single-rooted teeth needed to be extracted in the maxilla or mandible
  2. Patient in good general health as documented by self-assessment
  3. Patients must be committed to the study and sign the informed consent
  4. Adults only as participants

Exclusion Criteria:

  1. No systemic medical condition that could interfere with the surgical procedure or planned treatment.
  2. Smokers >20 cig/day
  3. Current pregnancy or breast feeding
  4. Radiotherapy or chemotherapy in head and neck area intravenous and oral bisphosphonates or anti-angiogenic drugs

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
No Intervention: Group 1: Control
In these post-extraction sockets no intervention takes place.
Experimental: Group 2: Allograft and collagen membrane
In order to perform alveolar ridge preservation in this group allograft and collagen membrane are placed in the post-extraction sockets.
Procedure: Allograft and collagen membrane
The post-extraction sockets will be filled with allograft particles and collagen membrane.
Other Names:
  • Group 2
Experimental: Group 3: Allograft and L-PRF membrane
In order to perform alveolar ridge preservation in this group allograft and L-PRF membrane are placed in the post-extraction sockets.
Procedure: Allograft and L-PRF membrane
The post-extraction sockets will be filled with allograft particles and L-PRF membrane.
Other Names:
  • Group 3
Experimental: Group 4: L-PRF membrane
In order to perform alveolar ridge preservation in this group L-PRF membrane is placed in post-extraction sockets.
Procedure: L-PRF
The post-extraction sockets will be filled with L-PRF membrane.
Other Names:
  • Group 4

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Radiographic assessment of the bone specimens
Time Frame: 3 months
Comparison of quantitative clinical alveolar ridge dimensions (in mm) between the four groups will be performed, 3 months after alveolar ridge preservation. Radiographic evaluation will take place and changes in horizontal dimension will be measured. The horizontal bone width of the ridge at the time of the extraction and after 3 months during the implant placement procedure will be measured in mm.
3 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Radiographic assessment of the bone specimens
Time Frame: 3 months
Comparison of quantitative clinical alveolar ridge dimensions (in mm) between the four groups will be performed, 3 months after alveolar ridge preservation. Radiographic evaluation will take place and changes in vertical dimension will be measured. The vertical bone height of the ridge at the time of the extraction and after 3 months during the implant placement procedure will be measured in mm.
3 months
Histological assessment of the bone harvested from the post-extraction sockets
Time Frame: 3 months
Measure quantitative histologic characteristics of new bone formation between the four groups after 3 months of alveolar ridge preservation by quantifying the distribution in (%) of new vital bone formed at the healed socket site.
3 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National and Kapodistrian University of Athens

Investigators

  • Study Chair: Nadia Lygidakis, Associate Professor, National and Kapodistrian University of Athens

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 5, 2022

Primary Completion (Estimated)

May 20, 2026

Study Completion (Estimated)

September 15, 2026

Study Registration Dates

First Submitted

January 18, 2026

First Submitted That Met QC Criteria

January 27, 2026

First Posted (Actual)

February 4, 2026

Study Record Updates

Last Update Posted (Actual)

February 4, 2026

Last Update Submitted That Met QC Criteria

January 27, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 415/23.05.2019

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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