AI Driven EX Versus Conventional in PFPS (AI- PFPS)

Artificial Intelligence Driven Exercises Versus Conventional Exercises Therapy for Patellofemoral

This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.This study is randomized controlled trial and includes 40 participants .These participants divided into 2 groups (A, B), each group will be assessed with 3 measurments (vas ,dynamic knee valgus, Kujala Anterior Knee Pain Scale) and each group will receive difeerent treatments.

The individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant .

Study Overview

• Status: Not yet recruiting
• Conditions: Patello Femoral Pain Syndrome
• Intervention / Treatment: Other: Ai driven EX; Other: conventional exercises therapy program

Detailed Description

PURPOSE : This study aims to investigate and compare the effect of AI driven exercises program versus the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome.

BACKGROUND:

Patellofemoral pain syndrome (PFPS) is one of the most common knee problems that disturb function and daily activities (Menek et al .,2025). Symptoms of PFPS can develop either slowly or abruptly, and pain tends to worsen with activities such as squatting, prolonged sitting, stair climbing, jumping, or running (Menek et al .,2025). PFPS affects approximately 25% of physically active individuals (Smith et al .,2018).

Core training significantly improves pain and functional limitations in patients with PFP and improves lower extremity motor performance to some extent (Y. Wang et al., 2024). These results draw more attention to the importance of the core muscle performance for both prevention and rehabilitation of the knee injuries

HYPOTHESES:

A-Primary Hypotheses:

This study will hypothesize that:

1. There will be no significant effect of AI driven exercises program on pain in treatment of patients PFPS .
2. There will be no significant effect of AI driven exercises program on function in treatment of patients PFPS .
3. There will be no significant differences of AI driven exercises program and on dynamic knee valgus in treatment of patients PFPS.
4. There will be no significant differences of conventional exercises therapy on pain in treatment of patients PFPS.
5. There will be no significant differences of conventional exercises therapy on function in treatment of patients PFPS.
6. There will be no significant differences of conventional exercises therapy dynamic knee valgus in treatment of patients PFPS.

RESEARCH QUESTION:

This study will try to answer the following questions:

This study will try to answer:What are the effects of of AI driven exercises program and the conventional exercises therapy program on pain, function and dynamic knee valgus angle in treatment of patellofemoral pain syndrome ?

• Study Type: Interventional
• Enrollment (Estimated): 40
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Alaa Hamdi Rizk, master degree; Phone Number: +201023429731 +201023429731; Email: alaa.potter35@gmail.com
• Study Contact Backup: Name: DINA SAYED ABD ALLAH, Lecturer of Physical Therapy; Phone Number: +20 12 8274205 +20 12 82742057; Email: drdinasayed_pt@yahoo.com

Study Locations

• Egypt
  • Cairo, Egypt
    • the out-patient clinic faculty of physical therapy, Cairo University,
    • Contact: Alaa hamdi rizk, master degree; Phone Number: +201023429731; Email: alaa.potter35@gmail.com
    • Contact: DINA SAYED ABD ALLAH, lecturer of PT; Phone Number: +2012 82742057 +2012 82742057; Email: drdinasayed_pt@yahoo.com
    • Principal Investigator: Alaa Hamdi Rizk, master
  • The Capital
    • Cairo, The Capital, Egypt
      • the out-patient clinic faculty of physical therapy, Cairo University,

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Their ages range from 18- 40 years old, including both genders (male & female).
• Their BMI will be ≤ 29 kg/m2.
• A traumatic knee pain persisting for at least three months.

Exclusion Criteria:

• Any congenital deformity of the lower limb,
• Any recent injuries and surgeries
• severe foot deformities such as hallux valgus and claw toe
• Neuromuscular and neurological disorders.- history of patellofemoral dislocation, subluxation .

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: ( AI driven EX for study group ); The individuals in group A(study group) will preceive AI driven exercises program while the individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant	Other: Ai driven EX; The individuals in group A(study group) will preceive AI driven exercises program . Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant
Other: conventional ex group; The individual in group B will receive conventional exercises therapy program. Participants in the both groups are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant .	Other: conventional exercises therapy program; The individual in group B will receive conventional exercises therapy program. Participants are prescribed a 6-week comprehensive exercises program (3 sessions per week) day after day and assessment procedure will be performed pre and post treatmeant

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Kujala Anterior Knee Pain Scale	a 13-item scale assessing knee functionality. The total Kujala score ranges from 0 to 100, with higher values indicating better performance. Additionally, The Kujala score is known for its reliability and validity in assessing patients with frozen PFPS	up to 6 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
visual analog scale	Pain intensity is assessed using the visual analog scale. Participants are instructed to indicate their pain level on a line ranging from 0 to 10, with 0 representing no pain and 10 indicating unbearable pain	up to 6 weeks

Collaborators and Investigators

• Sponsor: Cairo University
• Investigators: Study Director: SALWA FADL abdelmegeed, Professor of Physical Therapy, Cairo University

Study record dates

Study Major Dates

• Study Start (Estimated): February 26, 2026
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): January 1, 2027

Study Registration Dates

• First Submitted: January 26, 2026
• First Submitted That Met QC Criteria: February 9, 2026
• First Posted (Actual): February 12, 2026

Study Record Updates

• Last Update Posted (Actual): February 12, 2026
• Last Update Submitted That Met QC Criteria: February 9, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: P.T.REC/012/006096

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Data is available with correspondig offer on reasonable request

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No