Long-Term Health Effects of Previous Coronavirus Disease 2019 (COVID-19) in Patients Undergoing Preoperative Anesthesia Evaluation

June 2, 2026 updated by: Oğuz Kağan Bulut, Elazıg Fethi Sekin Sehir Hastanesi

Long-Term Clinical and Health Effects of Previous Coronavirus Disease 2019 (COVID-19) in Patients Presenting for Preoperative Anesthesia Evaluation

The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in persistent health problems in a significant proportion of individuals after recovery from the acute infection. These long-term manifestations, commonly referred to as post-COVID-19 condition or long COVID, may involve respiratory, cardiovascular, neurological, psychological, and general health domains. Understanding these sequelae is particularly important in patients undergoing preoperative anesthesia evaluation, as residual symptoms may influence perioperative risk assessment and clinical decision-making. This cross-sectional observational study aims to evaluate the long-term clinical and health effects of previous COVID-19 infection in adult patients presenting to the preoperative anesthesia clinic. Patients aged 18 years and older who report a history of confirmed COVID-19 infection will be included. Clinical data related to the acute infection period (disease severity, hospitalization, intensive care unit (ICU) admission, oxygen therapy, and radiological findings) will be retrospectively obtained from hospital records. At the time of preoperative assessment, participants will complete a structured post-COVID-19 clinical questionnaire to evaluate persistent symptoms across multiple organ systems. The study seeks to determine the prevalence and characteristics of long-term post-COVID-19 symptoms and to explore potential associations between acute disease severity and ongoing health complaints. No additional medical intervention will be performed as part of this research.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

400

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adult patients aged 18 years and older presenting to the preoperative anesthesia clinic of Elazığ Fethi Sekin City Hospital who report a previous laboratory-confirmed COVID-19 infection. The study population consists of surgical candidates undergoing routine preoperative evaluation. Clinical information regarding the acute COVID-19 period will be obtained retrospectively from hospital records, and persistent post-COVID symptoms will be assessed at the time of preoperative evaluation using a structured questionnaire.

Description

Inclusion Criteria:

  • Age ≥18 years

Presentation to the preoperative anesthesia clinic

Self-reported history of laboratory-confirmed COVID-19 infection

Ability to provide informed consent

Willingness to complete the post-COVID clinical questionnaire

Exclusion Criteria:

  • Age <18 years

No history of COVID-19 infection

Refusal to participate or incomplete questionnaire

Cognitive impairment or communication difficulties preventing reliable data collection

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Previous COVID-19 Patients
Adult patients (≥18 years) presenting to the preoperative anesthesia clinic who report a history of laboratory-confirmed COVID-19 infection. Clinical data related to the acute infection period will be retrospectively obtained from hospital records, and persistent post-COVID symptoms will be assessed using a structured questionnaire at the time of preoperative evaluation.
Other: Post-COVID Clinical Assessment
Structured post-COVID symptom questionnaire and retrospective clinical data review performed at the time of preoperative anesthesia evaluation. No therapeutic intervention is applied.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Prevalence of Persistent Post-COVID Symptoms
Time Frame: At the time of preoperative anesthesia assessment
Assessment of respiratory, cardiovascular, neurological, psychological, and general health symptoms using a structured post-COVID clinical questionnaire administered during preoperative anesthesia evaluation.
At the time of preoperative anesthesia assessment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Elazıg Fethi Sekin Sehir Hastanesi

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2025

Primary Completion (Estimated)

June 1, 2026

Study Completion (Estimated)

June 20, 2026

Study Registration Dates

First Submitted

February 21, 2026

First Submitted That Met QC Criteria

February 21, 2026

First Posted (Actual)

February 27, 2026

Study Record Updates

Last Update Posted (Actual)

June 4, 2026

Last Update Submitted That Met QC Criteria

June 2, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • EFSH-ANES-2025-19-23

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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