Impact of Combined Intravenous-Inhalational vs Inhalational Anesthesia on QoR-15 Recovery Scores in Gynecologic Surgery

March 28, 2026 updated by: melike kar, Sakarya University

Effects of Combined Intravenous-Inhalational Anesthesia Versus Inhalational Anesthesia on Postoperative Recovery in Gynecological Operations: A Comparison Based on QoR-15 Scores

This study aims to compare the effects of combined intravenous-inhalational anesthesia versus inhalational anesthesia alone on postoperative recovery in patients undergoing elective gynecologic surgery.

A total of 100 patients, aged 18-65 years and classified as ASA I-III, scheduled for elective gynecologic procedures at Sakarya University Faculty of Medicine Training and Research Hospital, will be included. The sample size was calculated based on the primary outcome, the Quality of Recovery-15 (QoR-15) score.

Patients will complete the QoR-15 questionnaire preoperatively, before knowing which anesthesia method will be applied. Postoperative QoR-15 scores will be collected on postoperative days 1 and 2, and intraoperative data will be obtained from anesthesia records.

The study evaluates postoperative recovery using QoR-15 scores, covering physical comfort, emotional state, psychological support, pain, and ability to perform daily activities. Higher scores indicate better recovery, whereas lower scores indicate impaired postoperative recovery.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

100

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Turkey (Türkiye)
      • Sakarya, Turkey (Türkiye), 54290
        • Recruiting
        • Sakarya University Training and Research Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. Patients aged 18-65 years
  2. Scheduled for elective gynecologic surgery at Sakarya University Faculty of Medicine Training and Research Hospital
  3. Classified as ASA I-III
  4. Able to understand and complete the QoR-15 questionnaire
  5. Provided written informed consent

Exclusion Criteria:

  1. Severe comorbidities (beyond ASA III)
  2. Patients with advanced neurological disease or cognitive impairment
  3. Known allergy to anesthetic drugs used in the study
  4. Classified as ASA IV-V
  5. Refusal to participate in the study
  6. Emergency or urgent surgery

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Combined Intravenous-Inhalational Anesthesia
Patients in this group will receive a combination of intravenous and inhalational anesthesia during elective gynecologic surgery. Postoperative recovery will be assessed using the QoR-15 questionnaire on postoperative days 1 and 2.
Drug: Combined Intravenous-Inhalational Anesthesia
Patients will receive a combination of intravenous anesthetic agents and inhalational anesthetic gases during elective gynecologic surgery. The specific anesthetic drugs and doses will follow routine clinical practice. Postoperative recovery will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire on postoperative days 1 and 2.
Active Comparator: Inhalational Anesthesia Only
Patients in this group will receive only inhalational anesthesia during elective gynecologic surgery. Postoperative recovery will be assessed using the QoR-15 questionnaire on postoperative days 1 and 2.
Drug: Inhalational Anesthesia Only
Patients will receive only inhalational anesthetic gases during elective gynecologic surgery, following routine clinical practice. Postoperative recovery will be assessed using the QoR-15 questionnaire on postoperative days 1 and 2.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Postoperative recovery using QoR-15
Time Frame: Postoperative Day 1 and Postoperative Day 2
Postoperative recovery will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire, a validated patient-reported outcome measure. The questionnaire evaluates physical comfort, emotional state, psychological support, pain, and ability to perform daily activities. Higher scores indicate better recovery.
Postoperative Day 1 and Postoperative Day 2

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Postoperative pain score
Time Frame: Postoperative hours 6, 12, and 24
Pain will be assessed using a standard numerical rating scale (0-10) at postoperative hours 6, 12, and 24. Higher scores indicate more pain.
Postoperative hours 6, 12, and 24
Postoperative nausea and vomiting (PONV) incidence
Time Frame: Postoperative hours 0-24
Incidence of nausea and vomiting will be recorded in the first 24 hours after surgery.
Postoperative hours 0-24
Length of stay in post-anesthesia care unit (PACU)
Time Frame: Postoperative period (PACU stay), assessed up to 10 days
Duration of stay in PACU will be recorded in minutes from admission to discharge.
Postoperative period (PACU stay), assessed up to 10 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sakarya University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 1, 2025

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

April 1, 2027

Study Registration Dates

First Submitted

March 14, 2026

First Submitted That Met QC Criteria

March 28, 2026

First Posted (Actual)

April 2, 2026

Study Record Updates

Last Update Posted (Actual)

April 2, 2026

Last Update Submitted That Met QC Criteria

March 28, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • E.513181 (Application No: 473)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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