Light and Anesthesia

April 1, 2026 updated by: Yi Feng, MD, Peking University People's Hospital

Effects and Mechanisms of Ambient Light Intensity on the Depth of General Anesthesia

The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include:

Does light condition affect the dosage of anesthetic medications during anesthesia? By what mechanism does light exposure exert an influence on anesthesia? Participants will be randomly allocated to either the light-shielded group or the non-light-shielded group.Patients in the light-shielded group will wear an eye shield during anesthesia.

The following data will be recorded for all patients:

Induction drug dosage Induction time Intraoperative anesthetic dosage Emergence time

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

66

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • China
      • Beijing, China, 100044
        • Recruiting
        • Peking University People's Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • a. Age between 18 and 65 years, regardless of gender;
  • b. ASA physical status I-II;
  • c. 18.5 ≤ BMI ≤ 28;
  • d. Signed written informed consent.

Exclusion Criteria:

  • a. Blindness or history of photosensitivity disorders;
  • b. Patients requiring medication for sleep, or with a history of sleep disorders;
  • c. Presence of neurological diseases;
  • d. Pregnancy;
  • e. Severe hepatic or renal dysfunction;
  • f. History of anesthetic drug abuse or alcohol abuse;
  • g. History of adverse anesthesia events (difficult airway, allergy to anesthetic agents).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: the light-shielded group
Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia.
Device: eye mask
Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia.
No Intervention: the non-light-shielded group

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The dose of sedative medications
Time Frame: Perioperative
The dose of sedative medications required during the induction period in patients
Perioperative

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Induction time of anesthesia
Time Frame: Perioperative
Induction time of anesthesia
Perioperative
total dose of sedative medications
Time Frame: during surgery
total dose of sedative medications required to maintain a certain range of anesthetic depth during surgery
during surgery
emergence time
Time Frame: Perioperative
emergence time after drug discontinuation
Perioperative

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Peking University People's Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 3, 2025

Primary Completion (Estimated)

May 1, 2026

Study Completion (Estimated)

May 1, 2026

Study Registration Dates

First Submitted

March 26, 2026

First Submitted That Met QC Criteria

April 1, 2026

First Posted (Actual)

April 8, 2026

Study Record Updates

Last Update Posted (Actual)

April 8, 2026

Last Update Submitted That Met QC Criteria

April 1, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2025-h018

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

To protect patient privacy and ensure the security of clinical data, the individual participant data (IPD) collected in this study will be used only for scientific analysis and publication related to this trial. No public disclosure, sharing, or uploading to public repositories is planned. Therefore, IPD will not be made available.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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