The Effects of PeptiStrong and Whey on Muscle Function In Older Adults

The Effects of PeptiStrong and Low Dose Whey Protein Versus High Dose Whey Protein Alone on Muscle Function In Older Adults

Examining the effects of PeptiStrong and protein on muscle function in older adults

Study Overview

• Status: Recruiting
• Conditions: Protein Supplementation; Muscle Function; Healthy Ageing; Muscle Health; Hand Grip Strength; Longevity; Peptides
• Intervention / Treatment: Dietary supplement: PeptiStrong + whey protein; Dietary supplement: Whey protein

Detailed Description

The aim of this study is to compare two protein drinks containing whey protein (derived from milk) in healthy adults aged 60 to 85 years. One group will consume a standard whey protein drink (20g), while the other group will consume a drink with half the total protein dose (10g) made of whey protein and PeptiStrong, a fava bean hydrolysate containing bioactive peptides.

The study will assess whether the lower protein drink containing PeptiStrong will lead to equal or greater improvements than the standard drink in physical function, such as the ability to stand up from a chair, walk at a normal pace, maintain balance, and grip strength. The study will also examine markers related to inflammation, fatigue, and quality of life.

The intended value of this research is to improve understanding of how targeted nutritional strategies may help maintain or improve muscle function in older adults. The findings may help inform future nutritional recommendations and the development of practical dietary interventions aimed at supporting healthy ageing and independence.

• Study Type: Interventional
• Enrollment (Estimated): 80
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Niamh Mohan, PhD; Phone Number: +353 1 430 1290; Email: mohan.niamh@nuritas.com

Study Locations

• United Kingdom
  • Liverpool, United Kingdom, L3 3AF
    • Recruiting
    • LJMU, Byrom Street
    • Contact: Graeme Close, Prof.; Phone Number: 0151 231 2121; Email: g.l.close@ljmu.ac.uk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Men and women aged 60 to 85 years at the time of enrolment
• Community-dwelling (living independently or with minimal assistance)
• Able to walk independently (with or without a walking aid) and complete simple physical function tests (such as standing up from a chair and walking short distances)
• Willing and able to attend two study visits at the research facility (baseline and end of study)
• Willing and able to consume a protein drink containing whey protein (derived from milk) once daily for 30 days
• Able to understand the study information and provide written informed consent

Exclusion Criteria:

• Any known food allergy or intolerance to fava bean protein or milk protein
• Diagnosed kidney disease or any medical condition where increased protein intake is contraindicated
• Yes to any of the answers on the "Older Adult Functional Assessment Screening Questionnaire"
• Individuals with implanted electronic devices
• Current or recent (within the past 3 months) participation in another clinical research study involving a nutritional or exercise intervention
• Conditions that significantly impair mobility or balance such that safe completion of the physical function tests is not possible

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: PeptiStrong + whey protein; 2.4g PeptiStrong (provides 1.6g protein) + 8.4g of whey protein = 10g total protein	Dietary supplement: PeptiStrong + whey protein; Fava bean protein hydrolysate containing bioactive peptides mixed with whey protein as dry powder for drinkable protein shake
Active Comparator: Whey protein; 20g whey protein	Dietary supplement: Whey protein; Whey protein as dry powder for drinkable protein shake

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hand Grip Strength via hand held dynamometer	Change from baseline to end of study in grip strength as assessed via hand held dynamometer	Baseline to Week 4

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Chair Stand Test - Part of short performance physical battery	Change from baseline to end of study in physical function assessment via chair stands. This test measures the time taken to complete 5 sit-to-stand repetitions in seconds. A lower time (fewer seconds) = better performance. As part of the full short performance physical battery it is converted to a subscore of 0-4, where a higher score = better performance	Baseline to week 4
Gait Speed as part of short performance physical battery	Change from baseline to end of study in physical function assessment assessed as time to walk a fixed distance in seconds and reporting in meters per second. Higher speeds indicate better performance. This is converted to a subscore of 0-4 within the full short performance physical battery	Baseline to week 4
6 Minute Walking Endurance Test	Change from baseline to end of study in physical function and endurance assessed as the total distance walked in 6 minutes in meters. A greater distance reflects better walking endurance and functional capacity.	Baseline to week 4
Balance test as part of short performance physical battery	Change from baseline to end of study in balance as assessed by the ability to hold three standing positions of increasing difficulty: side-by-side, semi-tandem, and tandem stance in seconds. Higher scores indicate better balance. The overall score is converted to a a sub-score of 0-4 within the full short performance physical battery.	Baseline to week 4
Balance assessment via force plates	Change from baseline to end of study in balance as assessed via force plates	Baseline to week 4
Quality of Life via the Sarcopenia Quality of Life (SarQoL®) Questionnaire	Change from baseline to end of study in quality of life as measured via subjective SarQOL questionnaire. The total score ranges from 0 to 100, with higher scores reflecting a higher quality of life.	Baseline to week 4
Fatigue via Multidimensional Fatigue Inventory Questionnaire	Change from baseline to end of study in self-reported fatigue as assessed via multidimensional fatigue inventory questionnaire. This 20-item questionnaire covers five dimensions: General Fatigue, Physical Fatigue, Mental Fatigue, Reduced Motivation, and Reduced Activity. Each subscale score ranges from 4 to 20, with higher scores indicating greater fatigue	Baseline to week 4
C-reactive protein (CRP) via blood test	Change from baseline to the end of study in inflammatory marker C-reactive protein (CRP) in serum as mg/L	Baseline to week 4
Interleukins via blood test	Change from baseline to the end of study in Interleukin inflammatory markers in serum as pg/mL	Baseline to week 4
Body composition: Muscle mass and body fat via bioelectrical impedance analysis	Change from baseline to end of study in muscle mass and body fat as measured by bioelectrical impedance analysis in kilograms and % of total body weight	Baseline to week 4

Collaborators and Investigators

• Sponsor: Nuritas Ltd
• Collaborators: Liverpool John Moores University
• Investigators: Principal Investigator: Graeme Close, Professor, Liverpool John Moore University

Study record dates

Study Major Dates

• Study Start (Actual): April 6, 2026
• Primary Completion (Estimated): July 30, 2026
• Study Completion (Estimated): October 30, 2026

Study Registration Dates

• First Submitted: March 30, 2026
• First Submitted That Met QC Criteria: April 7, 2026
• First Posted (Actual): April 14, 2026

Study Record Updates

• Last Update Posted (Actual): May 6, 2026
• Last Update Submitted That Met QC Criteria: April 30, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Keywords: Longevity; Muscle function; Protein supplementation; Physical performance; Healthy Aging; Bioactive peptides; Hand grip strength; Short performance physical battery; Nuritas; Liverpool John Moore University
• Additional Relevant MeSH Terms: Amino Acids, Peptides, and Proteins; Proteins; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Dairy Products; Milk; Dietary Proteins; Milk Proteins; Animal Proteins, Dietary; Whey; Whey Proteins
• Other Study ID Numbers: PEPVFH+60/26

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No