Low-Level Diode Laser Therapy on the Acceleration of Osseointegration Around Delayed Dental Implant

The Efficacy of Low-Level Diode Laser Therapy on the Acceleration of Osseointegration and Mucosal Phenotype Around Delayed Dental Implant: A Randomized Controlled Clinical Trial

Good quality soft tissue determines the possibility not only to obtain full primary wound closure during the bone defect reconstruction, but also assures effective implant treatment and stability of peri-implant condition.Moreover, it is very important to assure the proper emergence profile of the implant supported restorations, which give the opportunity to achieve the highest aesthetic appearance. In the long-term, the correct width and thickness of the attached keratinized tissue is the key point to ensure the stable position of the mucosal line around the implant's neck. The promising outcomes of laser on soft and hard tissue have been demonstrating in a variety of studies. Therefore, the aim of this clinical study is to evaluate the efficacy of LLDLT on enhancing osseointegration and on the peri-implant mucosal tissue around delayed dental implants.

Study Overview

• Status: Completed
• Conditions: Dental Implant
• Intervention / Treatment: Other: Dental implant + LLDL; Other: Dental implant

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Egypt
  • Kafr Elsheikh, Egypt
    • Kafr El-Sheikh University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Patients are systemically medically free.
• Ability to maintain good oral hygiene as evidenced in recall visits.
• Sufficient mesiodistal and interocclusal space and have an intact buccal bone contours which does not require bone augmentation procedures.
• Adequate bone quality.
• Keratinized tissue ≥ 2mm.
• Thickness of the gingiva ≥ 1 mm.

Exclusion Criteria:

• Presence of any systemic disease that could influence the outcome of the therapy.
• Presence of any risk factor e.g.; smoker, pregnant, lactating patients or any disease affect bone healing.
• Previous history of periodontal surgical treatment in quadrant selected for the study.
• Restorations or caries in the area to be treated and non-vital tooth.
• Adjacent teeth are tilted or rotated.
• Patients taking medications known to cause affect bone quality.
• Traumatic occlusion or Para-functional habits such as clenching or bruxism.
• Participation in other clinical trials.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: With laser	Other: Dental implant + LLDL; implant placement in the posterior areas and implants will be placed with application of LLDL. Preparation of the alveolus for delayed dental implant placement will be done and LLDL application according to manufacturer instructions
Active Comparator: Without laser	Other: Dental implant; It includes ten patients seeking for implant placement at the posterior areas and those patients will be received their implants only without application of LLDL .

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in marginal bone loss	To assess the change in marginal bone loss, the linear distance from a fixed reference point-typically the implant shoulder or CEJ-to the highest level of bone-to-tooth/implant contact is measured.	2 weeks, 1month, 2 months, and 6 months
Change in in implant stability	Ostell device will be used to assess implant stability	Immediately after surgery, 2 months and 6months postoperative.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in bone density	Radiographic examination of the patients will be done firstly pre-operative then at six months follow-up period post-operative by using CBCT device	2 weeks, 1month, 2 months, and 6 months

Collaborators and Investigators

• Sponsor: Hams Hamed Abdelrahman

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2024
• Primary Completion (Actual): October 1, 2025
• Study Completion (Actual): October 1, 2025

Study Registration Dates

• First Submitted: April 11, 2026
• First Submitted That Met QC Criteria: April 11, 2026
• First Posted (Actual): April 17, 2026

Study Record Updates

• Last Update Posted (Actual): April 17, 2026
• Last Update Submitted That Met QC Criteria: April 11, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Equipment and Supplies; Biomedical and Dental Materials; Manufactured Materials; Technology, Industry, and Agriculture; Prostheses and Implants; Dentistry; Dental Materials; Dental Prosthesis; Prosthodontics; Dental Implants
• Other Study ID Numbers: KFSIRB200-116

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No