- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT01579253
Combined O-(2-[18F]Fluoroethyl)-L-tyrosine (FET) Positron Emission Tomography (PET) and Simultaneous Magnetic Resonance Imaging (MRI) Follow-up in Re-irradiated Recurrent Glioblastoma Patients
Untersuchungen Zur Verlaufskontrolle Bei Re-Bestrahlung Von Glioblastompatienten Mittels Kombinierter [18F]FET-PET-Kernspintomographie
Studieoversigt
Status
Detaljeret beskrivelse
For glioblastoma (GBM) patients it has been proven that a [18F]FET-PET scan is very helpful especially in target volume definition and after the treatment, in turn, the combination of MRI and [18F]FET-PET is diagnostically most useful to distinguish between radiation necrosis and a real progressive disease.
The response to therapy is based on the newly formulated Revised Assessment in Neuro-Oncology (RANO) criteria. Kinetic and static [18F]FET-PET scans are useful to supplement this modality and its own prognostic value concerning relapsing patients will be examined.
The special feature of this study is the use of both modalities in parallel, allowing simultaneous acquisition of morphological changes, functional and molecular imaging.
Secondary methodological issues are dealt with, such as the relationship between contrast uptake, perfusion and [18F]FET uptake. In this regard, the hybrid imaging may serve for hypothesis generation, as in parallel in a unique way of contrast enhancement and tracer kinetics can be investigated (simultaneous contrast-enhanced analysis and tracer application).
In particular, FET kinetics are examined in more detail (for example, differences between increasing and decreasing kinetics) to find ways of how to use certain MRI sequences for better visualization of viable tumor tissue and vice versa .
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Studiekontakt
- Navn: Maximilian Niyazi, MD, MSc
- Telefonnummer: 00498970953770
- E-mail: Maximilian.Niyazi@med.uni-muenchen.de
Studiesteder
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Bavaria
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Munich, Bavaria, Tyskland, 81377
- Rekruttering
- University of Munich, Dep. of Radiation Oncology
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Ledende efterforsker:
- Maximilian Niyazi, MD, MSc
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- 18 - 75 years old
- histologically or magnetic resonance imaging proven recurrent glioblastoma
- re-irradiation possible
- willing and able to give free informed consent
Exclusion Criteria:
- not willing or able to give free informed consent
- pregnancy
- claustrophobia
- metallic objects or implanted medical devices in the body
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Samarbejdspartnere og efterforskere
Efterforskere
- Ledende efterforsker: Maximilian Niyazi, MD, MSc, Ludwig-Maximilians - University of Munich
Datoer for undersøgelser
Studer store datoer
Studiestart
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Sygdomme i nervesystemet
- Neoplasmer efter sted
- Neoplasmer, kirtel og epitel
- Gliom
- Neoplasmer, kimceller og embryonale
- Neoplasmer
- Glioblastom
- Neoplasmer i nervesystemet
- Neoplasmer i centralnervesystemet
- Astrocytom
- Neoplasmer efter histologisk type
- Neuroektodermale tumorer
- Neuroektodermale tumorer, primitive
- Neoplasmer, Neuroepithelial
- Neoplasmer, nervevæv
Andre undersøgelses-id-numre
- 361-11
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