- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT01789125
Smoking Termination / Anxiety Reduction Treatment (ST/ART) (START)
19. april 2019 opdateret af: Michael J. Zvolensky, Ph.D., University of Houston
Augmenting Smoking Cessation With Transdiagnostic CBT for Smokers With Anxiety
The primary aim of this research study is to enhance smoking cessation outcome among smokers with anxiety disorders.
The investigators are comparing two group treatment approaches: (1) An educational-supportive psychotherapy and standard smoking cessation treatment, and (2) An integrated smoking cessation and anxiety treatment program (START).
Both treatments also utilize nicotine replacement therapy.
Studieoversigt
Status
Afsluttet
Betingelser
Detaljeret beskrivelse
The chief objective of the proposed study is to develop an integrated standard smoking cessation treatment and transdiagnostic anxiety disorder treatment for smokers with anxiety disorders.
The intervention is designed to promote smoking cessation and reduce (a) anxiety symptoms, (b) depression, and (c) the cognitive factor of AS, thereby reducing three notable emotional risk factors of smoking cessation relapse, while at the same time targeting (d) nicotine withdrawal symptoms.
The intervention development approach will follow a staged model consistent with NIH guidelines for developing and standardizing behavioral therapies.
During the first year, startup activities will include piloting the integrated intervention on a subset of individuals, soliciting internal and external expert consultant and participant feedback, and development of the final treatment protocol.
The goal during this phase of the project will be to establish feasibility of treatment delivery, participant acceptability, and potential for an effect.
During the following two years, a pilot two-arm efficacy study will be undertaken.
The two arms of the randomized trial (RCT) will be: (a) the integrated smoking cessation treatment, consisting of a standard smoking cessation intervention (i.e., CBT-Smoking + Nicotine Replacement Therapy [NRT]) plus a transdiagnostic CBT for anxiety (Smoking Termination and Anxiety Reduction Treatment; START) or (b) standard smoking cessation intervention (i.e., CBT-Smoking + NRT) plus contact control (ST+CTRL).
The primary outcomes will be short- and long-term point prevalence abstinence (PPA) and time to first smoking lapse and relapse.
The following specific aims are proposed: 1.
To compare, in a pilot RCT, the effects of START vs. ST+CTRL on smoking cessation outcomes: Short- and longterm PPA.
The investigators expect that PPA will be higher, both in the short- and longterm, for those in the START condition compared to those in ST+CTRL.
Similarly, The investigators expect the rate of decline in abstinence over time to be slower in START than in ST+CTRL Time to first smoking lapse and time to smoking relapse.
The investigators expect mean time to first lapse and to relapse to be greater for those in the START compared to those in the ST+CTRL condition.
2. To compare, in a pilot RCT, the effect of START vs. ST+CTRL on the remission of anxiety disorders, anxiety and depressive symptoms, anxiety sensitivity, and nicotine withdrawal symptoms.
3. To explore the mechanisms by which START improves smoking cessation.
The investigators expect that: Treatments over time will directly cause changes in abstinence and withdrawal symptoms, AS, anxiety symptoms, depressed mood (i.e., the proposed mediators of change in abstinence); The effect of treatment on anxiety symptoms and depressed mood will be moderated by treatment condition, such that those receiving START will improve more than those receiving ST+CTRL Changes in each mediator over time will lead to improvements in abstinence over time, and decreases in AS over time will lead to improvements in anxiety symptoms and depressed mood over time.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
74
Fase
- Fase 1
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
Texas
-
Houston, Texas, Forenede Stater, 77204
- Anxiety and Health Research Laboratory and Substance Use Treatment Clinic, University of Houston
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 65 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- Ages 18-65 years old
- Capable of providing informed consent
- Willing to attend all study visits and comply with the protocol
- Daily smoker for at least one year
- Currently smoke an average of at least 6 cigarettes per day
- Report a motivation to quit smoking in the next 6 weeks of at least 5 on a 10-point scale
Exclusion Criteria:
- Use of other tobacco products
- Current or past psychotic disorders of any type, or comorbid psychiatric conditions that are relative or absolute contraindications to the use of any treatment option in the study protocol
- Currently suicidal or high suicide risk
- Current use of any pharmacotherapy or psychotherapy for smoking cessation not provided by the researchers during the quit attempt
- Unwilling to cease use of benzodiazepines or other fast-acting anxiolytics
- Concurrent psychotherapy initiated in the past three months, or ongoing anxiety psychotherapy
- Current or intended participation in a concurrent substance abuse treatment
- Insufficient command of English to participate in assessment or treatment
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Enkelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Aktiv komparator: Pædagogisk-støtte psykoterapi
Uddannelsesbaseret psykoterapi og standard rygestopbehandlingsprogram
|
Andre navne:
|
Aktiv komparator: Smoking Termination and Anxiety Reduction Treatment
Cognitive-behavioral treatment program that blends smoking cessation and anxiety reduction treatment strategies
|
Andre navne:
Integrated smoking cessation and anxiety reduction treatment
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Short- and long-term point prevalence abstinence
Tidsramme: Change from baseline at 1, 2, 4, 8, 10, 16, and 24 weeks post quit day.
|
The investigators will ask participants various questions about their abstinence.
The investigators will measure the length of time between when treatment ends and when/ if they start smoking again.
The unit of measure will be length of time in days.
|
Change from baseline at 1, 2, 4, 8, 10, 16, and 24 weeks post quit day.
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Time to first smoking lapse and relapse
Tidsramme: Change from baseline at 1, 2, 4, 8, 10, 16, and 24 weeks post quit day.
|
The investigators will ask participants to record the time (in days) of their first (if any) lapse in smoking and their relapse.
|
Change from baseline at 1, 2, 4, 8, 10, 16, and 24 weeks post quit day.
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. marts 2012
Primær færdiggørelse (Faktiske)
1. december 2015
Studieafslutning (Faktiske)
1. juni 2016
Datoer for studieregistrering
Først indsendt
8. februar 2013
Først indsendt, der opfyldte QC-kriterier
8. februar 2013
Først opslået (Skøn)
11. februar 2013
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
23. april 2019
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
19. april 2019
Sidst verificeret
1. april 2019
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 1R34DA03131301A1
- R34DA031313 (U.S. NIH-bevilling/kontrakt)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
INGEN
IPD-planbeskrivelse
Data will be made available upon request.
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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