- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT03936166
A Single and Multiple-Ascending Dose Study of CRN01941 in Healthy Adult Volunteers
2. november 2020 opdateret af: Crinetics Pharmaceuticals Inc.
A Double-Blind, Randomized, Placebo-Controlled, Single- And-Multiple-Ascending Dose Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of CRN01941 in Healthy Volunteers
This is a Phase 1, double-blind, randomized, placebo-controlled, single-dose and multiple-dose study of CRN01941 in up to 119 healthy male and female subjects.
This single-center study will be conducted in 3 parts: a single-ascending dose phase (up to 8 cohorts, 8 subjects/cohort), a multiple-ascending dose phase (up to 5 cohorts, 9 subjects/cohort), and single dose phase in elderly subjects (1 cohort, 10 subjects).
Studieoversigt
Status
Afsluttet
Betingelser
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
57
Fase
- Fase 1
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
Western Australia
-
Perth, Western Australia, Australien, 6009
- Linear Clinical Research
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 85 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ja
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- Male and female subjects 18 to 55 years of age, inclusive, at time of screening (Parts 1 and 2 only).
- Males and females subjects 65 to 85 years of age at screening (Part 3 only).
- Females must be non-pregnant and non-lactating, postmenopausal by history and confirmed by follicle stimulating hormone (FSH) >30 U/L at Screening, or surgically sterile.
- Male subjects must be surgically sterile or agree to use highly effective form of contraception when sexually active with a female partner of child bearing potential.
- Body mass index (BMI) of 18 to 32 kg/m2, inclusive at Screening.
- Willing to provide signed informed consent.
Exclusion Criteria:
- Any uncontrolled or active major systemic disease which makes study participation unsafe or could interfere with evaluation of the endpoints of the study.
- History or presence of malignancy within the past 5 years, not including treated basal cell carcinomas and in situ cervical neoplasia.
- Use of any investigational drug within the past 60 days.
- Have a medically significant abnormality observed during screening or admission.
- Use of any prior medication without approval of the investigator within 14 days prior to admission.
- Subjects with human immunodeficiency virus (HIV), hepatitis B or hepatitis C infections. Subjects with previous hepatitis C infection that is now cured may be eligible.
- History of or current alcohol or substance abuse in the past 12 months
- Any condition that in the opinion of the investigator would jeopardize the subject's appropriate participation in this Phase 1 study.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Firedobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: Enkelt stigende dosis (del 1)
|
Placebo
Placebo
Investigational drug
Investigational drug
|
Eksperimentel: Multipel stigende dosis (del 2)
|
Placebo
Placebo
Investigational drug
Investigational drug
|
Placebo komparator: Elderly Cohort (Part 3)
|
Placebo
Placebo
Investigational drug
Investigational drug
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
Number of participants with treatment emergent adverse events by severity
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Number of participants with serious adverse events (SAEs)
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Number of participants with clinically significant changes in vital signs
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Number of participants with ECG abnormalities
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Number of participants with clinical laboratory abnormalities
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Pharmacokinetics (AUC)
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Assessment of the plasma area under the curve of CRN01941
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Pharmacokinetics (Cmax)
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Assessment of the maximum observed plasma concentration of CRN01941
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Pharmacokinetics (Tmax)
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Assessment of the time to reach Cmax for CRN01941
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Pharmacokinetics (T1/2)
Tidsramme: Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Assessment of the elimination half-life of CRN01941
|
Part 1 - up to Day 8; Part 2 - up to Day 20; Part 3 - up to Day 8
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
29. april 2019
Primær færdiggørelse (Faktiske)
16. december 2019
Studieafslutning (Faktiske)
16. december 2019
Datoer for studieregistrering
Først indsendt
25. april 2019
Først indsendt, der opfyldte QC-kriterier
2. maj 2019
Først opslået (Faktiske)
3. maj 2019
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
4. november 2020
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
2. november 2020
Sidst verificeret
1. november 2020
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- CRN01941-01
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
INGEN
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ingen
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Placebo oral kapsel
-
Royan InstituteUkendtInfertilitetIran, Islamisk Republik
-
Pulmagen TherapeuticsAfsluttetAtopisk astmaDet Forenede Kongerige
-
VA Office of Research and DevelopmentAktiv, ikke rekrutterendeSelvmordstankerForenede Stater
-
Evelo Biosciences, Inc.AfsluttetPsoriasis | Atopisk dermatitisDet Forenede Kongerige
-
Sao Thai Duong Joint Stock CompanyBig Leap Clinical Research Joint Stock CompanyAfsluttet
-
Eidos Therapeutics, a BridgeBio companyTrukket tilbageTransthyretin-relateret (ATTR) familiær amyloid polyneuropatiForenede Stater
-
Georgetown UniversityNational Institutes of Health (NIH)RekrutteringDemens med Lewy BodiesForenede Stater
-
University of British ColumbiaCrohn's and Colitis CanadaTrukket tilbageInflammatoriske tarmsygdomme | Colitis ulcerosaCanada
-
University Hospital Schleswig-HolsteinUniversity of KielRekrutteringParkinsons sygdom | Ernæringsmæssige og metaboliske sygdomme | SukkerindtagTyskland
-
WockhardtAfsluttet