Drug Use Investigation for PAXIL Tablet

Patients prescribed PAXIL

Patients with depression/depressed state or panic disorder prescribed PAXIL during study period

Droga: Paroxetina

Presencia/ausencia de uso concomitante de fármacos metabolizados por CYP2D6

PAXIL inhibe la enzima CYP2D6 que metaboliza fármacos, y se tarda aproximadamente 1 semana después de la suspensión de PAXIL para que esta función CYP2D6 se recupere del efecto inhibidor. Dado que requiere atención si se administran fármacos metabolizados por CYP2D6 durante este período de recuperación, se decidió investigar la presencia/ausencia de uso de fármacos metabolizados por CYP2D6 dentro de las 2 semanas posteriores a la interrupción del tratamiento en pacientes en los que se suspendió el tratamiento con PAXIL. , así como la seguridad de los mismos.

Incidence of adverse events in Japanese subjects treated with paroxetine tablet based on prescribing information under the conditions of general clinical practice

Presence/absence of concomitant use of products containing Saint John's Wort (Hypericum perforatum; "SJW", hereinafter)

Although the action mechanism for this is not clear, SJW has been reported to have the action of inhibiting reuptake of serotonin, noradrenaline and dopamine, and to exhibit an antidepressant effect. Since PAXIL also acts to inhibit serotonin reuptake, concomitant use of products containing SJW is thought to have an effect upon the serotonin reuptake inhibiting action of PAXIL, so it was decided to check for concomitant use of products containing SJW and investigate the safety of such concomitant use.