Duloxetine Versus Placebo in the Prevention of Relapse of Major Depressive Disorder

Inclusion Criteria:

• Signed the informed consent
• Meet criteria for major depressive disorder without psychotic features.
• Have a level of understanding sufficient to provide informed consent and to communicate with the investigator and site personnel.
• Have had at least one other major depressive episode prior to the one being experienced at study entry.
• You are reliable and agree to keep all appointments for clinic visits, tests and procedures required by the protocol.

Exclusion Criteria:

• You have had treatment with a drug within the last 30 days that has not received regulatory approval at the time of study entry.
• Any women who are pregnant or breast feeding.
• If you have any serious medical illnesses other than major depressive disorder.
• If you have previously participated in a clinical trial for duloxetine.
• Any previous or current diagnosis of bipolar, schizophrenia, or other psychotic disorders.