Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure

Inclusion Criteria:

• Prehypertensive male and female subjects with SBP =120-140 mmHg or DBP =80-90 mmHg (as determined by seated office BP).
• Plasma uric acid level ≥5 mg/dl
• Ages 18-50
• non-smokers
• Subjects will need to remain in the San Diego area for the duration of the study and be accessible by telephone or email.

Exclusion Criteria:

• no current smoking in the prior 6 months.
• Any history of any serious medical conditions requiring close monitoring from physicians- such as liver impairment, chronic kidney disease, or diabetes mellitus. Participants not currently under the care of a physician for these conditions will be eligible for the study.
• Any history of gout, hypertension, hypercholesterolemia, morbid obesity.
• Any history of use xanthine oxidase inhibitors, antihypertensives, antiglycemic, and cholesterol lowering medications
• any history of illicit drug use within the last 6 months