Preoperative Nutritional Support in Malnutritional Cancer Patients
Prospective Study of Preoperative Nutritional Support in Malnutritional Pancreatobiliary Cancer Patients
Malnutrition patients are known to have more postoperative complications and mortality. And most of hepatobiliary-pancreatic cancer surgeries accompany high postoperative morbidity and mortality rate. Therefore for the malnourished patients anticipating major surgery, preoperative nutritional support is recommended according to the ASPEN (American society of parenteral and enteral nutrition) and ESPEN (European society of parenteral and enteral nutrition) guideline. However there is no prospective trial to prove the clinical impact of preoperative nutritional support for malnourished patients.
The purpose of this study is to evaluate the clinical impact of preoperative nutritional support for malnourished cancer patients anticipating HBP surgery. Primary objective is to compare the complication rate and secondary object is to compare the quality of life, hospital stay and cost.
調査の概要
詳細な説明
This is single arm study with historical comparison. The historical control group did not receiving nutritional support. In previous results show that about 25% complication rates. Complication rates are expected in the group receiving nutritional support is less than 10 % ( previous studies (NCCNCS-11-460)).
For support group, preoperative nutritional support is given for 5 or more days preoperatively by nutritional support program. Nutritional support program is briefly described below.
Interval: 5-10 days Contents: admission is required
- Calories: 30-35Kg, via enteral or parenteral
- Protein: 1.2-1.5g/Kg
- Lipid : 1-1.5g/Kg
- Mineral and vitamins supply
- Blood glucose control
- Daily monitoring by dietician and specialized nurse
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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-
Gyeonggi-do
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Goyang-si、Gyeonggi-do、大韓民国、410-769
- National Cancer Center
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Subjects in anticipating major surgery of hepatobiliary pancreatic cancer
Patients diagnosed with malnutrition (at least more than one)
- PG-SGA B or C
- Weight loss >10% within 6 month
- BMI <18.5
- Serum Albumin <3.0
- Age less than 80 years old over 20 years old
- Performance status (ECOG scale): 0-1
Adequate organ functions
- Hb ≥7.0 g/dl
- ANC ≥1,500/mm3
- PLT ≥80,000/mm3
- Liver function: AST/ALT ≤5×upper limit of normal
- Creatinine ≤2.0 ULN
Exclusion Criteria:
- Biopsy, drainage tube insertion, and other minor surgery
- palliative surgery
Serious illness or medical conditions, as follows;
- congestive heart failure (NYHA class III or IV)
- unstable angina or myocardial infarction within the past 6 months,
- significant arrhythmias requiring medication and conduction abnormality such as over 2nd degree AV block
- uncontrolled hypertension
- hepatic cirrhosis( ≥ Child class B)
- interstitial pneumonia, pulmonary adenomatosis
- psychiatric disorder that may interfere with and/or protocol compliance
- unstable diabetes mellitus
- uncontrolled ascites or pleural effusion
- active infection
- Pregnancy
- Any patients judged by the investigator to be unfit to participate in the study
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:処理
- 割り当て:非ランダム化
- 介入モデル:並列代入
- マスキング:なし(オープンラベル)
武器と介入
参加者グループ / アーム |
介入・治療 |
---|---|
実験的:nutritional support program apply
Preoperative nutritional support program is given for 5 or more days preoperatively by nutritional support program.
|
Nutritional support program is briefly described below. Interval: 5-10 days Contents: admission is required
|
介入なし:historical control group
Historical control group is that did not receiving
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
postoperative complication
時間枠:at discharge. (expected the duration of hospital stay of postoperation is 4~6 weeks.)
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expected the duration of hospital stay of postoperation is 4~6 weeks.
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at discharge. (expected the duration of hospital stay of postoperation is 4~6 weeks.)
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
postoperative hospital stay
時間枠:expected the duration of hospital stay of postoperation is 4~6 weeks.
|
expected the duration of hospital stay of postoperation is 4~6 weeks.
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expected the duration of hospital stay of postoperation is 4~6 weeks.
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quality of life
時間枠:preoperative, postoperative 14days
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preoperative, postoperative 14days
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preoperative, postoperative 14days
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postoperative cost( + nutritional support cost)
時間枠:at discharge. (expected the duration of hospital stay of postoperation is 4~6 weeks.)
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expected the duration of hospital stay of postoperation is 4~6 weeks.
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at discharge. (expected the duration of hospital stay of postoperation is 4~6 weeks.)
|
その他の成果指標
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
immunologic change(CD4/CD8) after nutritional support
時間枠:preoperative, postoperative 14days
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CD4/CD8, immunoglobulin G, M, A
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preoperative, postoperative 14days
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協力者と研究者
協力者
捜査官
- 主任研究者:SangJae Park、National Cancer Center, Korea
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
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nutritional support programの臨床試験
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Children's Health積極的、募集していない
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