A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease
A Study to Establish Genomic Bio Signatures of Ascending Aortic Aneurysms in Patients With Bicuspid and Tricuspid Aortic Valve Disease With Aortic Stenosis
연구 개요
상태
정황
상세 설명
The cause of bicuspid aortic valve (BAV) and its associated co morbidities is unknown. There is, however, evidence supporting a genetic cause for the BAV, Pedigree analysis of familial clustering initially directed investigators to a genetic cause of BAV. Subsequent studies on BAV patients using linkage analysis have demonstrated high heritability.
Early identification of those patients with BAV disease who are at risk for ascending aneurysm formation and its complications may allow early intervention to prevent rupture, dissection and emergent cardiac surgery in at risk patients. Conversely, identification of those patients with BAVs not at risk for aortic aneurysm formation would delineate which patients do not need close follow up of aortic size or prophylactic ascending aortic replacement at time of aortic valve replacement.
연구 유형
등록 (예상)
연락처 및 위치
연구 장소
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Texas
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Plano, Texas, 미국, 75093
- The Heart Hospital Baylor Plano
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
Inclusion Criteria:
- Patients > or = to 18 years of age
- Presenting with aortic stenosis and to undergo elective aortic valve replacement or repair with or without aortic aneurysm dilation repair
- Able to sign informed consent document
Exclusion Criteria:
- Patients unable to provide informed consent for any reason
- Patients with predominant aortic regurgitation valve disease
- Patients with other known connective tissue disorders (such as Marfan's Syndrome, Ehlers-Danlos Syndrome)
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
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45 specimens collected from BAV patients
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45 specimens collected from TAV patients
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15 specimens collected from CABG pts
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Determine differences in genetic expression profiles using mRNA transcriptional analysis
기간: 12 month
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Determine differences in genetic expression profiles using mRNA transcriptional analysis in the three groups: subjects with bicuspid aortic valves with aortic stenosis, subjects with tricuspid aortic valves with stenosis, and subjects without aortic valve disease.
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12 month
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Determine differences in the association between genetic expression profiles and aortic dilation in the two aortic valve disease groups.
기간: 12 months
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Determine differences in the association between genetic expression profiles and aortic dilation (in cm) among: subjects with bicuspid aortic valves and subjects with tricuspid aortic valves with aortic stenosis.
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12 months
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Determine the association between expression of inflammatory markers/impaired response to oxidative stress and stenotic aortic valve disease.
기간: 12 months
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Determine differences between expression of inflammatory markers/impaired response to oxidative stress and stenotic aortic valve disease among: subjects with bicuspid aortic valves and subjects with tricuspid aortic valves with aortic stenosis.
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12 months
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공동 작업자 및 조사자
수사관
- 수석 연구원: William Brinkman, MD, The Heart Hospital Baylor Plano
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
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