- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT01122186
Intervention Targeting Medication Adherence and Methamphetamine Use in HIV Positive Men (ACE) (ACE)
30 maj 2013 uppdaterad av: Jeffrey T. Parsons, Hunter College of City University of New York
Intervention Targeting Medication Adherence and Methamphetamine Use in HIV Positive Men
The primary aim is to test an innovative 8-session intervention, based on Motivational Interviewing and Cognitive Behavioral Skills-Training for the co-occurrence of methamphetamine use and highly active antiretroviral therapy (HAART) non-adherence among methamphetamine using HIV+ MSM in NYC, compared to an 8-session educational (ED) condition.
Participants in the intervention condition will report greater reductions in the number of days of methamphetamine use and viral load, and greater increases in CD4 counts and self-reported and objectively measured adherence than those in the education condition.
Studieöversikt
Status
Avslutad
Betingelser
Studietyp
Interventionell
Inskrivning (Faktisk)
210
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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New York
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New York, New York, Förenta staterna, 10018
- Center for HIV/AIDS Educational Studies and Training of Hunter College, CUNY
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år och äldre (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Manlig
Beskrivning
Inclusion Criteria:
- HIV+ (confirmed at baseline through documentation)
- Biologically male
- report sex with another man at least once
- report methamphetamine use at least three times in the past three months
- report less than 90% HAART medication adherence, as measured by the total number of days a participant missed an HIV medication in the last 30
- able to communicate with staff and complete a survey that is in English.
Exclusion Criteria:
- Unstable, serious psychiatric symptoms
- Currently suicidal/homicidal
- Evidence of gross cognitive impairment
- Self-reported current enrollment in a drug or HIV-related intervention or research study.
- Methadone use
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
---|---|
Experimentell: Intervention Condition
Eight sessions of Motivational Interviewing and Cognitive Behavioral Skills Training, adapted to target both MA use and medication adherence, as well as sexual risk behaviors and polydrug use.
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The first two sessions will be primarily Motivational Interviewing and begin with an introduction to the nature of treatment, emphasizing the client's autonomy, and explain that the purpose of the sessions is to explore feelings about their medication adherence, meth use, and any other issues, with the eventual goal of working towards any changes the client may wish to make.
During the third session, the client will complete an individualized functional analysis of recent occasions when the client missed medication, used MA and/or other substances, and engaged in risky sex (not necessarily all at the same time).
Sessions four through seven will focus on Cognitive Behavioral Skills Training for adherence, reducing or stopping meth use, reducing or stopping the combination of meth and other drug use, and avoiding risky sexual behavior.
The final session emphasizes maintenance of behavior change and relapse prevention.
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Aktiv komparator: Education Condition
Eight sessions of education with content designed to mirror the information covered in the intervention condition.
The content will be as follows: 3 sessions focusing on medication adherence; 3 sessions focusing on the dangers of methamphetamine use; 1 session addressing sexual risk; and 1 session addressing poly-substance use.
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During the first two sessions participants watch the documentary "Rock bottom" to receive information on Crystal Methamphetamine, and the possible interactions between HIV medications and recreational substances.
Sessions 3 and 4 focus on the importance of medication adherence, viral replication and mutation, and resistance.
Session 5 focuses on the negative effects of several recreational substances as well as the negative effects of mixing substances.
Session six discusses HIV stigma, transmission risk sexual behavior, and HIV disclosure.
Session 7 revisits medication adherence, focusing on dealing with medication side effects and communicating with health care providers.
The final session uses part of the documentary "Meth" which highlights issues of methamphetamine use through interviews with men in various stages of recovery.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
Adherence to HIV medication
Tidsram: every three months over the course of a year
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Participants in the intervention condition will report greater reductions in viral load, and greater increases in CD4 counts and self-reported adherence than those in the education comparison at at the end of the intervention period (3 months).
Those in the intervention condition will also maintain greater reductions in viral load, and greater increases in CD4 counts and self-reported adherence than those in the education comparison condition at the three follow-up assessments (6, 9, and 12 months).
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every three months over the course of a year
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Methamphetamine use.
Tidsram: every three months over the course of a year
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Participants in the intervention condition will report greater reductions in self-reported days of methamphetamine use than those in the education comparison at at the end of the intervention period (3 months).
Those in the intervention condition will also maintain greater reductions in self-reported days of methamphetamine use than those in the education comparison condition at the three follow-up assessments (6, 9, and 12 months).
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every three months over the course of a year
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
Sexual Risk
Tidsram: every three months over the course of a year
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Participants in the intervention condition will report greater reductions in high-risk sexual behavior compared to participants in the educational comparison condition.
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every three months over the course of a year
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Polysubstance use
Tidsram: every three months over the course of a year
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Participants in the intervention condition will report greater reductions in the use of substances other than methamphetamine, compared to participants in the educational comparison condition.
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every three months over the course of a year
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Användbara länkar
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart
1 september 2007
Primärt slutförande (Faktisk)
1 januari 2012
Avslutad studie (Faktisk)
1 januari 2012
Studieregistreringsdatum
Först inskickad
11 maj 2010
Först inskickad som uppfyllde QC-kriterierna
12 maj 2010
Första postat (Uppskatta)
13 maj 2010
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
3 juni 2013
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
30 maj 2013
Senast verifierad
1 maj 2013
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- 1R01DA023395 (U.S.S. NIH-anslag/kontrakt)
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .
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