Optimization of Patients Long-term Management After the Coronavirus Infection COVID-19 (OPTIMIST)

Inclusion Criteria:

For all groups:

• Informed consent signed by the patient.
• Men and women aged 18 and over.

Group COVID-19 (asymptomatic):

• Confirmed diagnosis of COVID-19 (positive SARS-CoV-2 RNA PCR test or history of IgM and / or IgG antibodies to SARS-CoV-2)
• Absence of any clinical symptoms associated with coronavirus infection.

Group Healthy:

• Contact with patients with symptomatic new coronavirus infection COVID-19 in the absence of personal protective equipment for at least 3 days.
• Absence of any clinical symptoms associated with coronavirus infection

Group COVID symptomatic:

• Confirmed diagnosis of previous COVID-19 (positive SARS-CoV-2 RNA PCR test or presence of IgM antibodies to SARS-CoV-2) in history.

• A severe course of COVID-19, characterized by one or more of the following symptoms:

  • Respiratory rate ≥ 30 in 1 min
  • Blood oxygen saturation (SpO2) ≤ 93%
  • The ratio of the partial tension of oxygen in arterial blood to the fraction of oxygen during inspiration (PaO2 / FiO2) <300
  • Lung tissue lesion> 50% and / or according to computed tomography CT-2 and higher
  • Septic shock / sepsis
  • Development of multiple organ failure
  • Cytokine storm

Exclusion Criteria:

• Pregnancy
• Covid-19 vaccination
• Any serious medical illness before coronavirus infection, as well as a permanent form of atrial fibrillation
• Regular intake of anti-inflammatory, antibacterial, cytostatic and immunosuppressive drugs
• Refusal to participate in the study