Cohort of STEMI Patients (STEMI)
CoHort of STEMI Patients
Ischemic heart disease is the leading cause of mortality in industrialized countries. ST elevated acute myocardial infarction is one of its most frequent and deadly manifestation. In the last 20 years, STEMI mortality has been reduced by 50% with the advent of timely reperfusion (primary percutaneous intervention) and significant progression in pharmacologic intervention.
However, death and heart failure incidence after STEMI remain elevated: up to 20% at one year.
Also, therapeutic management following international guidelines is standardized toward a "one-size fits all" therapeutic management.
In order to continue improving myocardial infarction outcomes, there is a need to better understand and individualize therapeutic targets such myocardial reperfusion injury, post reperfusion inflammation, adverse left ventricular (LV) remodeling ….
This knowledge will allow us to propose new therapeutic strategies and in the long run strive towards personalized medicine.
The aim objective of this cohort of STEMI patients is to identify new biological markers of injury and prognosis.
研究概览
研究类型
注册 (实际的)
联系人和位置
学习地点
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Bron、法国、69677
- Hôpital Cardiovasculaire Louis Pradel 28, Avenue du Doyen Lépine
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Age> 18 years
- Diagnosis of STEMI defined by ST segment elevation ≥ 0.2 mV in 2 contiguous leads on a 12-lead ECG.
- Primary PCI within 12 hours of symptoms onset.
Exclusion Criteria:
- Diagnosis of STEMI not confirmed by angiography
- Refusal to participate in the study or to sign the consent
- Inability to give information to the subject about the study
- Lack of medical social coverage
- Deprivation of civil rights
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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STEMI PATIENT Cohort
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PCI
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change in Troponin
大体时间：Day 0
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Dosage of Troponin at hospital admission and 4 hours after Percutaneous coronary intervention (PCI)
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Day 0
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Change in Creatine Kinase
大体时间：Day 0
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Dosage of Creatine Kinase at hospital admission and 4 hours after PCI
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Day 0
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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New York Heart Association (NYHA) Class
大体时间：at admission (Day 0)
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at admission (Day 0)
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Left ventricular ejection fraction (LVEF)
大体时间：24 hours after PCI (Day 1)
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LVEF measured by echocardiography
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24 hours after PCI (Day 1)
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合作者和调查者
调查人员
- 首席研究员：Michel OVIZE, Pr、Centre d'investigation Clinique , Hôpital Cardiovasculaire Louis Pradel 28, Avenue du Doyen Lépine - 69677 BRON
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
STEMI PATIENT Cohort的临床试验
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Gachon University Gil Medical CenterSoon Chun Hyang University; Sejong General Hospital; Inha University Hospital完全的
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Sykehuset i Vestfold HFHospital Pharmacy Enterprise, South Eastern Norway完全的
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Brigham and Women's HospitalGordon and Betty Moore Foundation完全的
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Brigham and Women's HospitalPatient-Centered Outcomes Research Institute主动，不招人
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SENAI CIMATEC招聘中
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Russian Academy of Medical Sciences未知
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Dana-Farber Cancer Institute邀请报名