HIV-Tb Confections Among HIV Patients
Prevalence of HIV-Tb co Infections Among HIV Patients and Their CD4+ T Cell Status-A Single Centre Study in India
研究概览
地位
条件
详细说明
Introduction
HIV infection increases the susceptibility of Mycobacterium Tuberculosis (M.Tb.) infection, and hastens its progression due to changes in immune status of the patients. In fact, tuberculosis is now the most common opportunistic infection in patients, who die from AIDS. Immune response in tuberculosis and other infections induces cytokines that enhance replication of HIV, and derives the patient to full blown AIDS. the prevalence of HIV/Tb co-infections have been reported to 0.4% to 20.1% from different regions of northern part of india. India is one of the six countries, those are accounted for 60 percent new cases of tuberculosis, and the BRICS countries collectively account for approximately 50 perce
nt cases of worldwide tuberculosis. The prevalence of multidrug resistant tuberculosis(MDR-TB.) is two-threefold higher in HIV co-infected patients; as HIV infected people rapidly acquire the active disease including resistant strain of M. Tb. and rapidly transmit the disease among population including PLHIV, who in turn, manifest the active drug resistant tuberculosis.
Methods
- This is cohort study among patients of HIV, attending ART (Antiretroviral therapy) center khagaria, Bihar, India during June' 2015 to May' 2016.
- Patients enrolled at the centre were subjected to screening for Mycobacterium tuberculosis infection by doing ESR, mantoux test, chest x-ray, sputum examination for acid fast bacillus (AFB) and nucleic acid amplification test.
- HIV/Tb co infected patients were given cotrimoxazole.
- Patients' data-for example, age, sex, co infection with tuberculosis would be recorded.
- Sputum positivity, radiological features, and extra pulmonary manifestations would be recorded and statistical analysis would be done
- Statistical analysis, such as, mean, standard deviation(SD), student T test, p-values would be done. P-value significance would be measured at p < .05.
研究类型
注册 (实际的)
联系人和位置
学习地点
-
-
Bihar
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Khagaria、Bihar、印度、851204
- ART centre, Sadar Hospital
-
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Patients of HIV+ enrolled ART centre
Exclusion Criteria:
- Lost to follow up patients (LFU)
- Patients died before the treatment started
- Children below 5 years
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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HIV mono infection
HIV Patients do not have active Mycobacterium Tuberculosis infection
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HIV-Tb. co infection
Patients with HIV and MycobacteriumTuberculosis co infections
|
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Prevalence of HIV/Tb. co Infections Among Patients of HIV Enrolled at ART Center.
大体时间:12 months
|
% Prevalence of HIV/Tb.
co infections= no.of HIV/Tb.
co infection (48)/total no. of enrolled patients of HIV including HIV/Tb.
co infections (219) x 100, i.e. 21.9%
|
12 months
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Comparing CD4+ T Cell Count in HIV-Tb. and HIV Cases.
大体时间:12 months
|
CD4 cell counts of HIV patients and HIV/co infection patients would be analysed by student T test, and p value would be estimated.
|
12 months
|
合作者和调查者
调查人员
- 首席研究员:Ranjan K Singh, M.D.、Physician cum nodal officer, ART centre, Khagaria, India.
出版物和有用的链接
一般刊物
- Getahun H, Gunneberg C, Granich R, Nunn P. HIV infection-associated tuberculosis: the epidemiology and the response. Clin Infect Dis. 2010 May 15;50 Suppl 3:S201-7. doi: 10.1086/651492.
- Festenstein F, Grange JM. Tuberculosis and the acquired immune deficiency syndrome. J Appl Bacteriol. 1991 Jul;71(1):19-30. No abstract available.
- Global Tuberculosis Report 2016, World Health Organisation, Geneva.
- Perrin F, Breen R, Lipman M. : HIV and Tuberculosis co-infection. ABC of HIV and AIDS. Michael W, et al (ed): Wiley-Blackwell, BMJ Publishing Group Limited 6:42-47,2012
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)?
研究数据/文件
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