A Drug Interaction Study of SY-004 Capsules in Healthy Subjects
2022年5月17日 更新者:Suzhou Yabao Pharmaceutical R&D Co., Ltd.
A Single Center, Open-label, Single Sequence Study to Evaluate the Potential Drug Interaction of CYP3A4 Inducer Rifampicin With SY-004 Capsules in Healthy Subjects
A single center, open-label, single sequence study was conducted to evaluate the potential drug interaction of CYP3A4 inducer rifampicin with SY-004 capsules in healthy subjects
研究概览
研究类型
介入性
注册 (实际的)
24
阶段
- 阶段1
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
-
-
Anhui
-
Wuhu、Anhui、中国、241000
- XIE Haitang
-
-
参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria:
- The subjects can communicate well with the researchers, understand and comply with the requirements of this study, and sign the informed consent voluntarily.
- Age on the day of signing the informed consent: healthy subjects aged 18 or above, both male and female.
- At the time of screening, male weight ≥ 50.0 kg, female weight ≥ 45.0 kg, 19.0 kg / m2 ≤ BMI ≤ 26.0 kg / m2.
- Fasting blood glucose ≥ 3.9 mmol / L and < 6.1 mmol / L.
- From one month before the informed consent to three months after the last medication, the subjects and their partners had no plans to have a child, take effective contraceptive measures voluntarily, and donate sperm or eggs.
Exclusion Criteria:
- Within 3 months before screening, a clinical trial was completed or withdrawn, or a clinical trial was in progress, or participated in other medical trial activities, and the researcher judged that it was not suitable to participate in this trial.
- With a history of serious systemic diseases or family history (including cardiovascular system, digestive system, urinary system, etc.), the researchers judged that the disease status could significantly change the absorption, distribution, metabolism and excretion of experimental drugs, or taking experimental drugs would increase the risk of subjects.
- Allergic constitution, or history of food allergy, or known allergy to study drug / similar drug, or to rifampicin or rifamycin antibiotics.
- Patients with previous orthostatic hypotension.
- Those who had a history of drug abuse, drug abuse or positive urine drug screening results in the past five years.
- Those who donated blood or lost more than 400ml in 4 weeks before screening, or received transfusion of blood or blood components in 4 weeks before screening, or planned to donate blood components within 3 months after the end of the study.
- Those who have a history of needle syncope or blood syncope, or who can't tolerate venipuncture for blood collection, or who have difficulty in blood collection.
- The patients with severe infection, trauma or major surgery within 4 weeks before the screening, or who plan to perform surgery during the study period (including but not limited to dental surgery).
- Use any prescription, over-the-counter, herbal or health products within 2 weeks before screening.
- Any drugs that inhibit or induce liver drug metabolizing enzymes were used within 30 days before screening.
- During the first three months of screening, the average alcohol intake was more than 14 units per week (1 unit = 360ml beer, 45ml spirits with 40% alcohol content or 150ml wine), or those who could not give up drinking during the test period, or those with positive alcohol breath.
- Smoking more than 5 cigarettes per day within 3 months before screening, or unwilling / unable to give up smoking during the trial.
- Those who have special requirements for diet and can not comply with the unified diet arrangement.
- It is not guaranteed that chocolate, any food or drink containing caffeine or possibly affecting the test results (such as pitaya, grapefruit, grapefruit, orange juice, mango, etc.) will be fasted 48 hours before administration and during the test.
- Pregnant or lactating women, or pregnancy test results were positive.
- The screening results of HBsAg, HCV, TP and HIV were positive.
- When screening, there was ALT > 1.5 times the upper limit of normal value( × ULN), or ast > 1.5 × ULN, or TBIL > 1.5 × ULN。
- When screening, the 12 lead ECG showed the following results: QT interval (qtcb) > 450ms (male) or > 470ms (female).
- The results of physical examination, vital signs, abdominal B-ultrasound (liver, gallbladder, pancreas, spleen and kidney), chest CT, ECG, laboratory examination items and test related auxiliary examination in screening period were not suitable for the participants.
- According to the judgment of the researcher, the subjects with other factors not suitable to participate in the experiment.
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:不适用
- 介入模型:顺序分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
实验性的:Group-drugs interaction
24 subjects were enrolled in this study.
The effects of rifampicin single dose and steady-state on the pharmacokinetics of sy-004 will be analyzed.
|
On the morning of D1, the subjects will take orally 80 mg of SY-004 Capsules on an empty stomach.Fasting will be performed within 4 hours after taking the medicine. From D8 to D14, the subjects will take orally 600 mg rifampicin before breakfast every day. On the day of D15, the subjects will take orally 600 mg rifampicin and 80 mg SY-004 Capsules on an empty stomach. From D16 to D21, subjects will take orally 600 mg of rifampicin before breakfast every day.The patient can be discharged from the hospital after completing the safety examination on D22. |
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Cmax
大体时间:22 days
|
Peak Plasma Concentration (Cmax) of SY-004 when SY-004 capsules were treated with rifampicin alone or in combination with rifampicin at steady-state level
|
22 days
|
AUC0-t
大体时间:22 days
|
Area under the plasma concentration versus time curve (AUC0-t)) of SY-004 when SY-004 capsules were treated with rifampicin alone or in combination with rifampicin at steady-state level
|
22 days
|
AUC0-∞
大体时间:22 days
|
Area under the plasma concentration versus time curve (AUC0-∞)) of SY-004 when SY-004 capsules were treated with rifampicin alone or in combination with rifampicin at steady-state level
|
22 days
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Tmax
大体时间:22 days
|
Peak Time (Tmax)of SY-004 when SY-004 capsules were treated with rifampicin alone or in combination with rifampicin at steady-state level
|
22 days
|
T1/2z
大体时间:22 days
|
Half time (T1/2z)of SY-004 when SY-004 capsules were treated with rifampicin alone or in combination with rifampicin at steady-state level
|
22 days
|
CLz/F
大体时间:22 days
|
Clearance (Clz/F)of SY-004 when SY-004 capsules were treated with rifampicin alone or in combination with rifampicin at steady-state level
|
22 days
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2021年7月6日
初级完成 (实际的)
2021年8月17日
研究完成 (实际的)
2021年8月17日
研究注册日期
首次提交
2021年5月15日
首先提交符合 QC 标准的
2021年5月25日
首次发布 (实际的)
2021年5月28日
研究记录更新
最后更新发布 (实际的)
2022年5月18日
上次提交的符合 QC 标准的更新
2022年5月17日
最后验证
2021年5月1日
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- SY004005
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
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