A fMRI(Functional Magnetic Resonance Imaging) Research Study to Learn More About Multiple Sclerosis and Individuals Potentially Experiencing Memory Difficulties

October 15, 2007 updated by: Neurognostics

A Double-Blind, Crossover Trial of Aricept® in Memory-Impaired Patients With Multiple Sclerosis: A Phase IV Demonstration of Functional MRI (fMRI) as a Surrogate Marker of Brain Activity Associated With Improvement in Memory Function

The purpose of this study is to determine if medication designed to improve memory will help patients with Multiple Sclerosis (MS) who are experiencing memory problems using fMRI to track brain activity.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Donepezil HCI (Aricept®) is an FDA-approved drug now used to enhance memory in patients with Alzheimer's disease. The aim of this project is to examine the effects of Donepezil HCI (Aricept®) on memory induced brain activation patterns in the context of a double-blind, crossover trial of patients with multiple sclerosis (MS). We will perform task activation experiments involving two cognitive domains. The proposed work on MS patients should yield new information regarding functional anatomic relationships during cognitive activity, and how these relationships change as a function of drug treatment.

Study Type

Interventional

Enrollment (Anticipated)

26

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Wisconsin
      • Milwaukee, Wisconsin, United States, 53226
        • Medical College of Wisconsin

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Between 18 and 65 years of age and experiencing some forgetfulness
  • Diagnosed with MS, currently taking Rebif® and experiencing mild memory problems
  • Participants will have stable medication dosages 1 month prior to testing
  • With no past or present neurological disorders (e.g. head trauma, seizures, encephalitis, stroke) except MS
  • With no known medical illnesses (e.g. diabetes, uncontrolled hypertension, arthritis)
  • With no psychiatric illness
  • With no current substance abuse
  • Females should not be pregnant or nursing
  • With no metallic devices in the body or claustrophobia

Exclusion Criteria:

  • Previous history of CNS disturbance other than MS
  • Severe motor or visual impairment that might interfere with the cognitive activation tasks
  • Prescribed psychoactive medications
  • Memory deficits caused by other significant neurological disease or psychiatric disorder
  • Active malignancy within one year of study participation
  • Known human immunodeficiency virus (HIV)
  • Current diagnosis of unstable glaucoma; history of myocardial infarction
  • Symptomatic Coronary Artery Disease within the last 12 months or evidence of ongoing ischemia or uncontrolled atrial or ventricular arrhythmias as shown by ECG; poorly controlled or labile hypertension
  • History of epilepsy or other seizure disorder within the past 12 months
  • Allergy or hypersensitivity to amphetamines or other sympathomimetic amines

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: CROSSOVER
  • Masking: DOUBLE

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Anatomic relationships during cognitive activity, and how these relationships change as a function of drug

Secondary Outcome Measures

Outcome Measure
fMRI as a surrogate marker for drug efficacy

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Neurognostics

Investigators

  • Principal Investigator: Safwan Jaradeh, MD, Medical College of Wisconsin

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2004

Study Completion (ACTUAL)

October 1, 2007

Study Registration Dates

First Submitted

April 14, 2006

First Submitted That Met QC Criteria

April 14, 2006

First Posted (ESTIMATE)

April 18, 2006

Study Record Updates

Last Update Posted (ESTIMATE)

October 16, 2007

Last Update Submitted That Met QC Criteria

October 15, 2007

Last Verified

October 1, 2007

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MSA1-904

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Relapsing-Remitting Multiple Sclerosis

Clinical Trials on Donepezil HCI (drug)

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Gabon

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe