Affective Processing in Depression and Epilepsy

July 8, 2009 updated by: Northwell Health

Affective Processing in Depression and Epilepsy; An fMRI Study

The goal of this study is to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Detailed Description

Symptoms of depression is commonly seen in patients with epilepsy. There are similarities and differences between depressive symptoms in epilepsy when compared with primary depression. Through the use of fMRI (Functional MRI), we hope to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Study Type

Observational

Enrollment (Actual)

14

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • New York
      • Manhasset, New York, United States, 11030
        • North Shore Lij Health System

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

There are four study groups.

  1. Healthy Controls
  2. Subjects with epilepsy only
  3. Subjects with primary depression only
  4. Subjects with epilepsy and depressive symptoms.

Description

For Control Group

Inclusion Criteria:

  • Healthy adults of 18 years of age or older.

Exclusion Criteria:

  • Subject has no history of affective disorders
  • Subject scores higher than 5 on Hamilton Depression Rating Scale
  • Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
  • Subject is pregnant
  • Subject is unable to undergo a MRI

Epilepsy Only Group

Inclusion Criteria:

  • Subject is at least 18 years of age
  • Subject has confirmed temporal lobe epilepsy (TLE)

Exclusion Criteria:

  • Subject has a history of depression
  • Subject scores higher then 5 on Hamilton Depression Rating Scale
  • Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
  • Subject is pregnant
  • Subject is unable to undergo a MRI

Depression Only Group

Inclusion Criteria:

  • Subject is at least 18 years of age
  • Subject scores between 12 and 18 on Hamilton Depression Rating Scale

Exclusion Criteria:

  • Subject scores higher than 18 on Hamilton Depression Rating Scale
  • Subject is currently being medicated for depression
  • Subject has history of major depression or dysthymia
  • Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
  • Subject is pregnant
  • Subject is unable to undergo a MRI

Depression and Epilepsy Group

Inclusion Criteria:

  • Subject has confirmed temporal lobe epilepsy (TLE)
  • Subject scores between 12 and 18 on Hamilton Depression Rating Scale

Exclusion Criteria:

  • Subject has history of major depression or dysthymia
  • Subject is currently on medication for depression
  • Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
  • Subject is pregnant
  • Subject is unable to undergo a MRI

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Northwell Health

Investigators

  • Principal Investigator: Alan Ettinger, M.D., Northwell Health

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2008

Primary Completion (Actual)

June 1, 2009

Study Completion (Actual)

June 1, 2009

Study Registration Dates

First Submitted

March 3, 2009

First Submitted That Met QC Criteria

March 3, 2009

First Posted (Estimate)

March 4, 2009

Study Record Updates

Last Update Posted (Estimate)

July 9, 2009

Last Update Submitted That Met QC Criteria

July 8, 2009

Last Verified

July 1, 2009

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • GCRC 0246
  • 08-128

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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