Affective Processing in Depression and Epilepsy

Affective Processing in Depression and Epilepsy; An fMRI Study

The goal of this study is to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Study Overview

• Status: Terminated
• Conditions: Depression; Epilepsy; Healthy
• Intervention / Treatment: Other: fMRI; Other: Hamilton Depression Rating Scale; Other: Beck's Depressive Inventory; Other: Interictal Dysphoric Disorder Inventory (IDDI)

Detailed Description

Symptoms of depression is commonly seen in patients with epilepsy. There are similarities and differences between depressive symptoms in epilepsy when compared with primary depression. Through the use of fMRI (Functional MRI), we hope to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

• Study Type: Observational
• Enrollment (Actual): 14

Contacts and Locations

Study Locations

• United States
  • New York
    • Manhasset, New York, United States, 11030
      • North Shore Lij Health System

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

There are four study groups.

1. Healthy Controls
2. Subjects with epilepsy only
3. Subjects with primary depression only
4. Subjects with epilepsy and depressive symptoms.

Description

For Control Group

Inclusion Criteria:

• Healthy adults of 18 years of age or older.

Exclusion Criteria:

• Subject has no history of affective disorders
• Subject scores higher than 5 on Hamilton Depression Rating Scale
• Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
• Subject is pregnant
• Subject is unable to undergo a MRI

Epilepsy Only Group

Inclusion Criteria:

• Subject is at least 18 years of age
• Subject has confirmed temporal lobe epilepsy (TLE)

Exclusion Criteria:

• Subject has a history of depression
• Subject scores higher then 5 on Hamilton Depression Rating Scale
• Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
• Subject is pregnant
• Subject is unable to undergo a MRI

Depression Only Group

Inclusion Criteria:

• Subject is at least 18 years of age
• Subject scores between 12 and 18 on Hamilton Depression Rating Scale

Exclusion Criteria:

• Subject scores higher than 18 on Hamilton Depression Rating Scale
• Subject is currently being medicated for depression
• Subject has history of major depression or dysthymia
• Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
• Subject is pregnant
• Subject is unable to undergo a MRI

Depression and Epilepsy Group

Inclusion Criteria:

• Subject has confirmed temporal lobe epilepsy (TLE)
• Subject scores between 12 and 18 on Hamilton Depression Rating Scale

Exclusion Criteria:

• Subject has history of major depression or dysthymia
• Subject is currently on medication for depression
• Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder
• Subject is pregnant
• Subject is unable to undergo a MRI

Study Plan

How is the study designed?

Collaborators and Investigators

• Sponsor: Northwell Health
• Investigators: Principal Investigator: Alan Ettinger, M.D., Northwell Health

Study record dates

Study Major Dates

• Study Start: June 1, 2008
• Primary Completion (Actual): June 1, 2009
• Study Completion (Actual): June 1, 2009

Study Registration Dates

• First Submitted: March 3, 2009
• First Submitted That Met QC Criteria: March 3, 2009
• First Posted (Estimate): March 4, 2009

Study Record Updates

• Last Update Posted (Estimate): July 9, 2009
• Last Update Submitted That Met QC Criteria: July 8, 2009
• Last Verified: July 1, 2009

More Information

Terms related to this study

• Keywords: Epilepsy; Depression; fMRI; Neurology; Healthy Controls
• Additional Relevant MeSH Terms: Behavioral Symptoms; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Mood Disorders; Epilepsy; Depression; Depressive Disorder
• Other Study ID Numbers: GCRC 0246; 08-128