Visual Exploration and Attention: Studies in Patients With Schizophrenia and Autism Spectrum Disorders

August 25, 2016 updated by: University Hospital, Strasbourg, France

Visual Exploration and Attention : Studies in Patients With Schizophrenia and Autism Spectrum Disorders

The aim of the protocol is to better understand the impairments in visual processing, as such impairments may induce social interaction difficulties in subjects with autism spectrum disorders (adults and children) and schizophrenia, like face exploration.The same protocol will be used for the three populations, each population being compared with matched controls. The explorations are designed to test two different hypotheses regarding the mechanisms of the visual perception difficulties of the two populations. Even though difficulties to extract the global form of objects have been described in both subjects with autism and schizophrenia, we will test two different hypotheses for the two populations. We will test the hypothesis that subjects with autism display an advantage for the processing of local information arising at an early level of processing, whereas disorders observed in patients with schizophrenia originate from attention disorders. The protocol includes three consecutive studies, each one being applied in each of the three populations.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

140

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
      • Brumath, France, 67170
        • Recruiting
        • Pôle départemental du Centre de Ressources Autisme pour adultes (67) - Etablissement public de santé Alsace-Nord (site de Brumath)
        • Contact:
        • Principal Investigator:
          • HOCHNER Arielle, MD
        • Sub-Investigator:
          • WEINER Luisa, MD
      • Colmar, France, 68000
        • Recruiting
        • Centre de Ressources Autisme Pôle adultes (68) - Espace Autisme 68
        • Contact:
        • Principal Investigator:
          • MURAD Ayman, MD
      • Loos, France, 59120
        • Recruiting
        • Clinique Lautréamont
        • Contact:
        • Principal Investigator:
          • GONIN Olivier, MD
      • Strasbourg, France, 67000
        • Recruiting
        • Pôle régional du Centre de Ressources Autisme pour enfants et adolescents - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - Pôle de Psychiatrie - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - HUS
        • Contact:
        • Principal Investigator:
          • GRAS-VINCENDON Agnès, MD
        • Sub-Investigator:
          • CHABAUX-DELARAI Catherine, MD
      • Strasbourg, France, 67091
        • Recruiting
        • INSERM U666 ; Pôle de Psychiatrie - Service de Psychiatrie Adulte- HUS
        • Contact:
        • Principal Investigator:
          • GIERSCH Anne, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

7 years to 55 years (Child, Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Psychiatry clinic in Strasbourg and Brumath. Pedopsychiatry Clinic in Strasbourg. Residents of Strasbourg and Brumath

Description

Inclusion Criteria:

  • IQ above 70, as evaluated with the WAIS III in adults and with the WISC in children
  • signed consent
  • DSM IV criteria in case of autism spectrum disorders or schizophrenia

Exclusion Criteria:

  • grave or non stabilized somatic pathology
  • pathology affecting the central nervous system; other than the studied pathologies
  • intake of psychotropic drug, except for patients
  • invalidating sensory processes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
A1
Patients with schizophrenia
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Names:
  • Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
A2
Control subjects matched individually with patients with schizophrenia
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Names:
  • Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
B1
Adult subjects with autism
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Names:
  • Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
B2
Control subjects matched individually with adult subjects with autism
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Names:
  • Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
C1
Children with autism
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Names:
  • Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
C2
Control subjects matched individually with children with autism
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Names:
  • Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Strasbourg, France

Investigators

  • Principal Investigator: Anne GIERSCH, Institut National de la Santé Et de la Recherche Médicale, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2009

Primary Completion (Anticipated)

December 1, 2016

Study Completion (Anticipated)

December 1, 2016

Study Registration Dates

First Submitted

June 2, 2009

First Submitted That Met QC Criteria

June 3, 2009

First Posted (Estimate)

June 4, 2009

Study Record Updates

Last Update Posted (Estimate)

August 26, 2016

Last Update Submitted That Met QC Criteria

August 25, 2016

Last Verified

August 1, 2016

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2008-A01459-46

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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