Cognitive Function in Adults With Cardiac Disease (TimePoints)

The purpose of this study is to identify cardiac patients' degree of unappreciated mild impairment in cognitive function patterns of cognitive function, and influencing factors related to cognitive functioning during hospitalization. The results from the study will contribute to tailoring the delivery of patient education to optimize patient understanding of information in future clinical practice.

It is hypothesized that the study will demonstrate the following:

1. The degree of cognitive function for patients hospitalized in a CICU will be below the scores for normal functioning adults.
2. Patients with acute cardiovascular conditions will score differently in cognitive functioning at various times throughout their hospitalization.

3. Relationships between cognitive function and following variables:

   • Patients with greater sleep deprivation or fatigue will exhibit lower cognitive functioning.
   • Patients with greater hunger will exhibit lower cognitive functioning.
   • Patients who are experiencing greater anxiety will exhibit lower cognitive functioning.
   • Patients who are experiencing depression will exhibit lower cognitive functioning.
   • Patients who have undergone or will undergo shortly treatment or procedures will exhibit lower cognitive functioning.

Study Overview

• Status: Completed
• Conditions: Cognitive Impairment; Cardiac Disease

• Study Type: Observational
• Enrollment (Actual): 66

Contacts and Locations

Study Locations

• United States
  • Ohio
    • Cleveland, Ohio, United States, 44106
      • University Hospitals of Cleveland

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 100 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Adult patients hospitalized in the University Hospitals' (Cleveland, OH) coronary intensive unit (CICU) being treated for acute cardiovascular conditions

Description

Inclusion Criteria:

• Admission to the Cardiac Intensive Care Unite for acute cardiological issues during time of enrollment.
• Patients with NYHA class I, II, III, and IV.
• 18 years or older and must be awake and conversant at time of enrollment.

Exclusion Criteria:

• History of neurological disorder or injury (e.g., Alzheimer's Disease, dementia, stroke, seizures).
• Moderate or severe head injury (defined as > 24 hours loss of consciousness)
• Past or current history of severe psychiatric illness. Specifically, psychotic disorders (e.g., schizophrenia) and bipolar disorder. Potential participants will not be excluded on the basis of managed depression or anxiety disorder. These conditions are common in cardiac patients and their exclusion may limit the generalizability of findings.
• 5 years past or current history of alcohol or drug abuse (defined by DSM-IV criteria).
• History of learning disorder or developmental disability (defined by DSM-IV criteria).
• Renal failure requiring dialysis.
• History of sleep apnea (defined through previous sleep studies).
• Severely ill individuals, including those who are sedated, on a ventilator, exhibiting acute hemodynamic changes, and/or those deemed inappropriate by patient's physician to participate in study.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Hospitalized Cardiac Patient; Adults admitted to Coronary intensive unit being treated for acute cardiovascular conditions

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Cognitive Function as measured by Modified Mini Mental Status (3MS) Examination	Up to 3 hours prior to discharge
Cognitive Function as measured by Rey Auditory Verbal Learning	Up to 3 hours prior to discharge
Cognitive Function as measured by Trails testing	Up to 3 hours prior to discharge
Cognitive Function as measured by Digit Span Backwards	Up to 3 hours prior to discharge
Cognitive Function as measured by Rey Auditory Verbal Learning Long Delay	Up to 3 hours prior to discharge
Cognitive Function as measured by Rey Auditory Verbal Learning Long Delay and Recognition	Up to 3 hours prior to discharge
Cognitive Function as measured by Frontal Assessment Battery	Up to 3 hours prior to discharge

Collaborators and Investigators

• Sponsor: University Hospitals Cleveland Medical Center
• Investigators: Principal Investigator: Richard Josephson, MS, MD, University Hospitals Cleveland Medical Center

Study record dates

Study Major Dates

• Study Start: July 1, 2009
• Primary Completion (Actual): December 1, 2010
• Study Completion (Actual): December 1, 2010

Study Registration Dates

• First Submitted: January 5, 2010
• First Submitted That Met QC Criteria: January 5, 2010
• First Posted (Estimate): January 6, 2010

Study Record Updates

• Last Update Posted (Actual): April 22, 2022
• Last Update Submitted That Met QC Criteria: April 14, 2022
• Last Verified: April 1, 2022

More Information

Terms related to this study

• Keywords: Cognitive Impairment; Cognitive Function; Cardiac Disease; Hospitalization
• Additional Relevant MeSH Terms: Mental Disorders; Cardiovascular Diseases; Neurocognitive Disorders; Cognition Disorders; Heart Diseases; Cognitive Dysfunction
• Other Study ID Numbers: 05-09-25