The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels

May 3, 2020 updated by: Amrita Ahluwalia, Queen Mary University of London

The Effects of C-type Natriuretic Peptide on Endothelial Function Following Ischaemia-Reperfusion in the Human Forearm

To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood. In this study we are looking at the function of the blood vessels of the forearm, as a substitute for those in the heart

Study Overview

Status

Withdrawn

Conditions

Intervention / Treatment

Study Type

Interventional

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
      • London, United Kingdom, EC1M 6BQ
        • Queen Mary University London

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy human volunteers on no systemic medication, excepting the oral contraceptive pill

Exclusion Criteria:

  • History of medical illness
  • Unwillingness to sign consent form
  • Use of non-OCP medications
  • Hypertension on examination of the blood pressure

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: CNP
Infusion of CNP prior to IR injury
Drug: C-type natriuretic peptide (CNP)
360 pmol/min for 15 minutes intra-arterially
Drug: Acetylcholine
2 stepped infusions for a total 9min per limb, totalling 1.05micromoles per limb
Placebo Comparator: Saline
Effect of saline infusion prior to IR injury
Drug: Acetylcholine
2 stepped infusions for a total 9min per limb, totalling 1.05micromoles per limb
Drug: Saline
Sodium Chloride 0.9% intra-arterially 0.5ml/min

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change in area under curve dose-response to acetylcholine after IR injury
Time Frame: 2h
2h

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Queen Mary University of London

Collaborators

University College, London

Investigators

  • Principal Investigator: Ahluwalia Amrita, BSc PhD, Queen Mary University London

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

January 1, 2020

Primary Completion (Anticipated)

January 1, 2022

Study Completion (Anticipated)

January 1, 2023

Study Registration Dates

First Submitted

February 23, 2010

First Submitted That Met QC Criteria

February 24, 2010

First Posted (Estimate)

February 25, 2010

Study Record Updates

Last Update Posted (Actual)

May 5, 2020

Last Update Submitted That Met QC Criteria

May 3, 2020

Last Verified

May 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 007143

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Ischaemia-reperfusion (IR) Injury

Clinical Trials on C-type natriuretic peptide (CNP)

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Cyprus

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe