Low Carbohydrate and Conventional Diets Associated to Resistance Training on Muscle Fitness and Health Markers (LCD-RT)

Combined Effects of Resistance Training and Low Carbohydrate or Conventional Diets on Strength, Muscle Mass, Body Composition, Blood Lipids and Endothelium Function

The purpose of this study was to compare the effects of two different diets (low carbohydrate - LCD and conventional - CONV) on body composition, strength performance, muscle mass and biomarkers of health in overweight adults submitted to resistance training (RT). It has been hypothesized that LCD would produce higher rates of weight loss and that both diets would be useful to maintain muscle mass and strength and biomarkers of health.

Study Overview

• Status: Completed
• Conditions: Obesity; Overweight
• Intervention / Treatment: Other: macronutrient and energy manipulation

Detailed Description

Overweight and obesity prevalence has increased worldwide. Current guidelines recommend health behavior modifications, including better eating habits and regular physical activity (including resistance training - RT) as a strategy to control and prevent the problem. Traditionally, diets poor in energy and fat (conventional diets - CONV) have been recommended to promote losses in body and fat masses; however, there has been recently a growing interest in the academic community to investigate the effects of low carbohydrate diet (LCD) on health outcomes, since this kind of diet appears to be more effective for reducing body mass as compared to CONV. Nevertheless, evidences are scarce regarding the effects of LCD associated to RT on body composition, strength performance, blood lipids, endothelium function and other markers of health, demanding the development of clinical trials aiming to determine the combined health effects of these interventions.

• Study Type: Interventional
• Enrollment (Actual): 21
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • RJ
    • Rio de Janeiro, RJ, Brazil, 20748-900
      • Laboratory Crossbridges

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 60 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• BMI equal or over 25 kg/m2
• resistance trained at least 12 weeks

Exclusion Criteria:

• upper or lower limbs injury
• pregnancy
• diabetes
• use of ergogenics, stimulants or drugs
• history of dislipidemias
• arterial hypertension

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: exercise training	Other: macronutrient and energy manipulation
Experimental: Diet counseling; Outcomes of the study may enhance diet counseling	Other: macronutrient and energy manipulation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
body mass	Measured always at the same time of the day on a calibrated weight scale	eight weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle strength	Measured using resistance exercise machines (isotonic) in four exercise movements	eight weeks
Endothelial function	Measured using a two dimensional color spectral Doppler ultrasound equipped with a 14MHz linear transducer. Subject laid down comfortably in the supine position with the right arm slightly abduced. After locating the brachial artery, the transducer was placed on the anteromedial face of the right arm, perpendicular to the centerline of the arm, 5-10 cm above the antecubital fossa, over the artery.	eight weeks
muscle thicknesses	Measured with a ultrasoundo bidimensional in Mode B, with a 7,5MHz transducer on the anatomical sites knee extensor muscles and elbow flexors and extensors.	eight weeks
markers of renal function	Measured using conventional and satandardized laboratory methods with subjects fasting for 12 hours	eight weeks
body composition	Measured with skinfold calipers and using prediction equations to determine body fat and lean body mass.	eight weeks

Collaborators and Investigators

• Sponsor: Universidade Gama Filho
• Investigators: Principal Investigator: Paulo Sergio C Gomes, Ph.D., Universidade Gama Filho

Study record dates

Study Major Dates

• Study Start: September 1, 2006
• Primary Completion (Actual): January 1, 2008
• Study Completion (Actual): August 1, 2008

Study Registration Dates

• First Submitted: March 17, 2010
• First Submitted That Met QC Criteria: March 30, 2010
• First Posted (Estimate): March 31, 2010

Study Record Updates

• Last Update Posted (Estimate): March 31, 2010
• Last Update Submitted That Met QC Criteria: March 30, 2010
• Last Verified: November 1, 2007

More Information

Terms related to this study

• Keywords: body mass index; resistance exercise; endothelial function; hypertrophy; blood lipids
• Additional Relevant MeSH Terms: Body Weight; Overweight
• Other Study ID Numbers: UGF-01-2010