Improving Spatial and Temporal Vision in Adult and Juvenile Amblyopia

An Active Approach to Treat Amblyopia: Perceptual Learning and Video Games

Sponsors

Lead sponsor: University of California, Berkeley

Collaborator: National Eye Institute (NEI)

Source University of California, Berkeley
Brief Summary

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.

Detailed Description

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. Our previous findings (see CITATIONS) show that the adult amblyopic brain is still plastic and malleable, suggesting that active approach is potential useful in treating amblyopia. The goal of this project is to assess the limits and mechanisms of neural plasticity in both normal and amblyopic spatial vision. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia. Research participants will be asked to practice a visual discrimination task (perceptual learning) or to play video games with the amblyopic eye for a period of time. A range of visual functions will be monitored during the course of treatment.

Overall Status Recruiting
Start Date July 2015
Completion Date May 2025
Primary Completion Date May 2025
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Amblyopic vision 9 months
Secondary Outcome
Measure Time Frame
Spatial vision 9 months
Temporal vision 9 months
Enrollment 50
Condition
Intervention

Intervention type: Behavioral

Intervention name: Perceptual learning

Description: Research participants will be asked to practice a visual discrimination task (e.g. position acuity, contrast sensitivity, stereoacuity etc) in our laboratory for a period of time (2 hrs/day, 5 days/week).

Arm group label: Perceptual learning

Intervention type: Behavioral

Intervention name: Video Games

Description: Research participants will be asked to play "off-the-shelf" video games in our laboratory for a period of time (2 hrs/day, 5 days/week).

Arm group label: Video game

Intervention type: Behavioral

Intervention name: Occlusion therapy

Description: Research participants will be required to cover the good eye during the day in order to push the brain to use the amblyopic eye (2 hrs/day, 5 days/week for 2-4 weeks).

Arm group label: Occlusion therapy

Eligibility

Criteria:

Inclusion Criteria:

- adults and children (>5 years old) with normal vision or amblyopia

- amblyopia: interocular VA difference of at least 0.1 logMAR

Exclusion Criteria:

- any ocular pathological conditions, nystagmus

Gender: All

Minimum age: 5 Years

Maximum age: 75 Years

Healthy volunteers: Accepts Healthy Volunteers

Overall Official
Overall Contact

Last name: Roger W Li, OD, PhD

Email: [email protected]

Location
facility status contact investigator Minor Hall 486, School of Optometry, University of California, Berkeley Roger W Li, OD,PhD [email protected] Roger W Li, OD, PhD Principal Investigator
Location Countries

United States

Verification Date

April 2019

Responsible Party

Responsible party type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 3
Arm Group

Arm group label: Perceptual learning

Arm group type: Experimental

Description: Patients will be asked to practice a range of visual discrimination tasks for a period of time (each therapy session:1-2 hrs, 4-5 sessions/wk for ~1-6 months).

Arm group label: Occlusion therapy

Arm group type: Experimental

Description: The fellow sound will be covered with a standard eye patch for a period of time (1-2 hrs/day, 4-5 days/wk for ~1-3 months). The idea is to push the brain to use the weaker amblyopic eye.

Arm group label: Video game

Arm group type: Experimental

Description: Patients will be asked to play videogames for a period of time (each therapy session:1-2 hrs, 4-5 sessions/wk for ~1-6 months).

Study Design Info

Allocation: Randomized

Intervention model: Crossover Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Source: ClinicalTrials.gov