- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05818787
Effect of Vestibular Perceptual Learning on Vestibular Thresholds and Balance
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Four training paradigms will be evaluated in 4 cohorts of older 10 adults (N=40; Ages 60 to 89). The first training protocol will be a roll tilt training protocol previously shown to reduce roll tilt thresholds. The remaining three training protocols will include the parameters (i.e., plane of tilt, feedback schema, and difficulty level) found most effective following a series of basic science human subject experiments. As such, each cohort will perform perceptual training using a combination of the following training parameters:
- Tilt Plane: training stimuli will either be in (A) the roll plane, (B) the pitch plane, (C) in the anatomical plane of vertical semi-circular canals (i.e., 45 degrees between the roll and pitch planes).
- Difficulty Level: As was done in a published study of roll tilt perceptual training, the training stimuli will be adjusted during each training session using an adaptive staircase procedure. Older adults will train using either a (A) 2-Down/1-Up (i.e., the size of the tilt stimulus decreases after 2 consecutive correct responses and increases after each incorrect response), (B) 3-Down/1-Up, or (C) 6-Down/1-Up staircase. The respective staircases target a stimulus that, on average, should yield an accuracy level of 70.7%, 79.4%, and 89.1%, and thus represent a progressive decrease in difficulty level.
- Feedback Method: During training, the accuracy of perceptual judgement (e.g., recognizing a left vs. right tilt motion) will be provided to the subject using one of three feedback schema: (A) an auditory stimulus indicating when an answer is correct, as well as incorrect, (B) a visual stimulus provided after the subject responds (i.e., chooses left or right) during the return of the chair to an upright position (i.e., tilting back to the start), or (C) a combination of auditory feedback and visual feedback.
Specifically, one cohort of older adults will use the training protocol that, after completion of pilot experiments, is found to most effectively reduce tilt thresholds in young adults, another cohort will use the training protocol that yields the best change in balance in young adults, and the last cohort will use the remaining training protocol judged to best reduce thresholds AND yield the best sway changes. A training protocol may be repeated in more than one older adult cohort (e.g., if best threshold and best balance change are achieved via the same protocol in young adults) however each older adult participant recruited will only be randomly assigned to a single test condition. All other elements of the training not outlined above, (e.g., 6 days for testing/training visits, etc.) will mimic the published protocol.
The targeted dates for each assessment and intervention period are shown, however, to permit greater adherence to the study protocol, tests of retention will be accepted if they occur within 7 to 10 days after the post-test (for the one-week follow-up) or 30 to 40 days after the post-test (for the one-month follow-up).
Intervention-First arm:
- Day 1: Pre-test assessment
- Days 2-5: Active perceptual learning intervention
- Day 6: Post-test assessment
- Day 13: One-week retention assessment
- Day 36: One-month retention assessment
- Days 37-40: Control intervention
- Day 41: Post-test assessment
Control-First arm:
- Day 1: Pre-test assessment
- Days 2-5: Control intervention
- Day 6: Post-test / Pre-Test assessment
- Days 7 to 10: Active perceptual learning intervention
- Day 11: Post-test assessment
- Day 18: One-week retention assessment
- Day 41: One-month retention assessment
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Daniel M Merfeld, PhD
- Phone Number: 614-485-9179
- Email: merfeld.6@osu.edu
Study Contact Backup
- Name: Andrew R Wagner, PT, DPT, PhD
- Phone Number: 614-485-9179
- Email: andrew.wagner@osumc.edu
Study Locations
-
-
Ohio
-
Columbus, Ohio, United States, 43212
- The Ohio State University Wexner Medical Center
-
Principal Investigator:
- Daniel M Merfeld, PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Must be able to stand
- No leg or foot amputations
- No lower limb braces
- Not currently feeling dizzy/lightheaded
- Not currently pregnant by self-report
- Weight <= 275 pounds
Exclusion Criteria:
- Severe head trauma or traumatic brain injury
- Any vestibular disorder (e.g., Meniere's Disease, Vestibular Migraine, Unresolved benign paroxysmal positional vertigo (BPPV), Vestibular hypofunction, except that due to aging, PPPD) as assessed by a Vestibular OtoNeurologist and Neurotologist using clinical diagnostic tests described in proposal plus any additional clinical evaluations they identify
- History of seizures
- Neurologic illness or condition determined by an Otoneurologist known to impact vestibular or balance function(e.g., stroke, neurodegenerative disorders, demyelinating illness)
- Major psychiatric (e.g., panic disorder, psychosis, etc.) disorder
- Any of the following eye diseases or conditions: amblyopia (or "lazy eye") or history of amblyopia, diagnosis of age-related macular degeneration, retina dystrophy, glaucoma, cataracts, or any other eye condition that limits vision to worse than 20/40
- Recent (<6 months) orthopedic injuries of the lower extremities (e.g., plantar fasciitis, ankle, knee or hip injury, back strain/herniated disc, …).
- Upper extremity injuries requiring current sling immobilization
- Recent surgery
- Any other severe health problem (heart disease, pulmonary disease, cancer, etc.).
- Vision in both eyes must be better than 20/40 with best correction
- Due to the potential for nausea with some of the motion stimuli, and to protect fetus and mother, pregnant women will also be excluded from this study
- Since every possible exclusionary factor cannot be predicted, additional exclusion criteria may be required
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Training Protocol 1 - Intervention First
Participants will complete a roll tilt training protocol previously shown to reduce roll tilt thresholds.
The training stimulus parameters are as follows: 0.5 Hz roll tilt motion, stimulus size will be adjusted based upon subject responses using a 2-down, 1-up (2D/1U) staircase, and only auditory feedback will be provided.The training protocol will be completed first, followed by the placebo intervention.
|
The participants will be tilted and asked to indicate their perceived direction of self-motion (e.g., left or right).
Feedback will be provided to promote learning (i.e., improved perception of motion).
Feedback will only be provided after the subject response, and thus vestibular (i.e., self-motion) perception is required to judge the direction of the tilt stimulus.
After each trial, a 3 second period of rest will be given.
Each day of training will include three blocks of one-hundred trials each.
Testing will take place in the dark (except for aims where a visual cue is provided).
Subjects will be seated on a motion platform with a 5-point harness and the head restrained.
Noise cancelling earpieces (along with a white noise signal) will be used to reduce external noise.
Subjects will always be asked to make a decision (e.g.
left versus right) by pressing buttons with their left or right hands.
If not certain, subjects are instructed to provide their best guess.
Other Names:
The placebo (or control) task will consist of oculomotor exercises that the subject will complete at home (i.e., outside of the lab).
The oculomotor exercises will include saccadic eye movements performed in the horizontal and vertical planes.
All movements will be completed within a limited, comfortable range of motion with the head remaining stationary.
As the control intervention will be performed with the head stationary and in a seated position, no change in self-motion perception or balance is expected to result from the control (i.e., placebo) task.
|
Experimental: Training Protocol 1 - Placebo First
Participants will complete a roll tilt training protocol previously shown to reduce roll tilt thresholds.
The training stimulus parameters are as follows: 0.5 Hz roll tilt motion, stimulus size will be adjusted based upon subject responses using a 2D/1U staircase, and only auditory feedback will be provided.
The placebo intervention will be completed first, followed by the roll tilt training intervention.
|
The participants will be tilted and asked to indicate their perceived direction of self-motion (e.g., left or right).
Feedback will be provided to promote learning (i.e., improved perception of motion).
Feedback will only be provided after the subject response, and thus vestibular (i.e., self-motion) perception is required to judge the direction of the tilt stimulus.
After each trial, a 3 second period of rest will be given.
Each day of training will include three blocks of one-hundred trials each.
Testing will take place in the dark (except for aims where a visual cue is provided).
Subjects will be seated on a motion platform with a 5-point harness and the head restrained.
Noise cancelling earpieces (along with a white noise signal) will be used to reduce external noise.
Subjects will always be asked to make a decision (e.g.
left versus right) by pressing buttons with their left or right hands.
If not certain, subjects are instructed to provide their best guess.
Other Names:
The placebo (or control) task will consist of oculomotor exercises that the subject will complete at home (i.e., outside of the lab).
The oculomotor exercises will include saccadic eye movements performed in the horizontal and vertical planes.
All movements will be completed within a limited, comfortable range of motion with the head remaining stationary.
As the control intervention will be performed with the head stationary and in a seated position, no change in self-motion perception or balance is expected to result from the control (i.e., placebo) task.
|
Experimental: Training Protocol 2 - Intervention First
Participants will complete the training protocol that, after completion of preliminary basic science experiments, is found to most effectively reduce tilt thresholds in young adults.
The potential training stimulus parameters are as follows: (1) roll tilt, pitch tilt, LARP tilt, or RALP tilt motion, (2) stimulus size will be adjusted based upon subject responses using either a 2D/1U, three-down, one-up (3D/1U), or six-down, one-up (6D/1U) staircase, and (3) either auditory, visual, or combined auditory+visual feedback will be provided.
The training protocol will be completed first, followed by the placebo intervention.
|
The participants will be tilted and asked to indicate their perceived direction of self-motion (e.g., left or right).
Feedback will be provided to promote learning (i.e., improved perception of motion).
Feedback will only be provided after the subject response, and thus vestibular (i.e., self-motion) perception is required to judge the direction of the tilt stimulus.
After each trial, a 3 second period of rest will be given.
Each day of training will include three blocks of one-hundred trials each.
Testing will take place in the dark (except for aims where a visual cue is provided).
Subjects will be seated on a motion platform with a 5-point harness and the head restrained.
Noise cancelling earpieces (along with a white noise signal) will be used to reduce external noise.
Subjects will always be asked to make a decision (e.g.
left versus right) by pressing buttons with their left or right hands.
If not certain, subjects are instructed to provide their best guess.
Other Names:
The placebo (or control) task will consist of oculomotor exercises that the subject will complete at home (i.e., outside of the lab).
The oculomotor exercises will include saccadic eye movements performed in the horizontal and vertical planes.
All movements will be completed within a limited, comfortable range of motion with the head remaining stationary.
As the control intervention will be performed with the head stationary and in a seated position, no change in self-motion perception or balance is expected to result from the control (i.e., placebo) task.
|
Experimental: Training Protocol 2 - Placebo First
Participants will complete the training protocol that, after completion of preliminary basic science experiments, is found to most effectively reduce tilt thresholds in young adults.
The potential training stimulus parameters are as follows: (1) roll tilt, pitch tilt, left anterior/right posterior (LARP) tilt, or right anterior/left posterior (RALP) tilt motion, (2) stimulus size will be adjusted based upon subject responses using either a 2D/1U, 3D/1U, or 6D/1U staircase, and (3) either auditory, visual, or combined auditory+visual feedback will be provided.
The placebo intervention will be completed first, followed by the roll tilt training intervention.
|
The participants will be tilted and asked to indicate their perceived direction of self-motion (e.g., left or right).
Feedback will be provided to promote learning (i.e., improved perception of motion).
Feedback will only be provided after the subject response, and thus vestibular (i.e., self-motion) perception is required to judge the direction of the tilt stimulus.
After each trial, a 3 second period of rest will be given.
Each day of training will include three blocks of one-hundred trials each.
Testing will take place in the dark (except for aims where a visual cue is provided).
Subjects will be seated on a motion platform with a 5-point harness and the head restrained.
Noise cancelling earpieces (along with a white noise signal) will be used to reduce external noise.
Subjects will always be asked to make a decision (e.g.
left versus right) by pressing buttons with their left or right hands.
If not certain, subjects are instructed to provide their best guess.
Other Names:
The placebo (or control) task will consist of oculomotor exercises that the subject will complete at home (i.e., outside of the lab).
The oculomotor exercises will include saccadic eye movements performed in the horizontal and vertical planes.
All movements will be completed within a limited, comfortable range of motion with the head remaining stationary.
As the control intervention will be performed with the head stationary and in a seated position, no change in self-motion perception or balance is expected to result from the control (i.e., placebo) task.
|
Experimental: Training Protocol 3 - Intervention First
Participants will complete the training protocol that, after completion of preliminary basic science experiments, is found to most effectively improve balance in young adults.
The potential training stimulus parameters are as follows: (1) roll tilt, pitch tilt, LARP tilt, or RALP tilt motion, (2) stimulus size will be adjusted based upon subject responses using either a 2D/1U, three-down, one-up (3D/1U), or six-down, one-up (6D/1U) staircase, and (3) either auditory, visual, or combined auditory+visual feedback will be provided.
The training protocol will be completed first, followed by the placebo intervention.
|
The participants will be tilted and asked to indicate their perceived direction of self-motion (e.g., left or right).
Feedback will be provided to promote learning (i.e., improved perception of motion).
Feedback will only be provided after the subject response, and thus vestibular (i.e., self-motion) perception is required to judge the direction of the tilt stimulus.
After each trial, a 3 second period of rest will be given.
Each day of training will include three blocks of one-hundred trials each.
Testing will take place in the dark (except for aims where a visual cue is provided).
Subjects will be seated on a motion platform with a 5-point harness and the head restrained.
Noise cancelling earpieces (along with a white noise signal) will be used to reduce external noise.
Subjects will always be asked to make a decision (e.g.
left versus right) by pressing buttons with their left or right hands.
If not certain, subjects are instructed to provide their best guess.
Other Names:
The placebo (or control) task will consist of oculomotor exercises that the subject will complete at home (i.e., outside of the lab).
The oculomotor exercises will include saccadic eye movements performed in the horizontal and vertical planes.
All movements will be completed within a limited, comfortable range of motion with the head remaining stationary.
As the control intervention will be performed with the head stationary and in a seated position, no change in self-motion perception or balance is expected to result from the control (i.e., placebo) task.
|
Experimental: Training Protocol 3 - Placebo First
Participants will complete the training protocol that, after completion of preliminary basic science experiments, is found to most effectively improve balance in young adults.
The potential training stimulus parameters are as follows: (1) roll tilt, pitch tilt, LARP tilt, or RALP tilt motion, (2) stimulus size will be adjusted based upon subject responses using either a 2D/1U, 3D/1U, or 6D/1U staircase, and (3) either auditory, visual, or combined auditory+visual feedback will be provided.
The placebo intervention will be completed first, followed by the roll tilt training intervention.
|
The participants will be tilted and asked to indicate their perceived direction of self-motion (e.g., left or right).
Feedback will be provided to promote learning (i.e., improved perception of motion).
Feedback will only be provided after the subject response, and thus vestibular (i.e., self-motion) perception is required to judge the direction of the tilt stimulus.
After each trial, a 3 second period of rest will be given.
Each day of training will include three blocks of one-hundred trials each.
Testing will take place in the dark (except for aims where a visual cue is provided).
Subjects will be seated on a motion platform with a 5-point harness and the head restrained.
Noise cancelling earpieces (along with a white noise signal) will be used to reduce external noise.
Subjects will always be asked to make a decision (e.g.
left versus right) by pressing buttons with their left or right hands.
If not certain, subjects are instructed to provide their best guess.
Other Names:
The placebo (or control) task will consist of oculomotor exercises that the subject will complete at home (i.e., outside of the lab).
The oculomotor exercises will include saccadic eye movements performed in the horizontal and vertical planes.
All movements will be completed within a limited, comfortable range of motion with the head remaining stationary.
As the control intervention will be performed with the head stationary and in a seated position, no change in self-motion perception or balance is expected to result from the control (i.e., placebo) task.
|
Experimental: Training Protocol 4 - Intervention First
Participants will complete the training protocol that, after completion of preliminary basic science experiments, is found to most effectively reduce tilt thresholds AND improve balance in young adults.
The potential training stimulus parameters are as follows: (1) roll tilt, pitch tilt, LARP tilt, or RALP tilt motion, (2) stimulus size will be adjusted based upon subject responses using either a 2D/1U, 3D/1U, or 6D/1U staircase, and (3) either auditory, visual, or combined auditory+visual feedback will be provided.
The training protocol will be completed first, followed by the placebo intervention.
|
The participants will be tilted and asked to indicate their perceived direction of self-motion (e.g., left or right).
Feedback will be provided to promote learning (i.e., improved perception of motion).
Feedback will only be provided after the subject response, and thus vestibular (i.e., self-motion) perception is required to judge the direction of the tilt stimulus.
After each trial, a 3 second period of rest will be given.
Each day of training will include three blocks of one-hundred trials each.
Testing will take place in the dark (except for aims where a visual cue is provided).
Subjects will be seated on a motion platform with a 5-point harness and the head restrained.
Noise cancelling earpieces (along with a white noise signal) will be used to reduce external noise.
Subjects will always be asked to make a decision (e.g.
left versus right) by pressing buttons with their left or right hands.
If not certain, subjects are instructed to provide their best guess.
Other Names:
The placebo (or control) task will consist of oculomotor exercises that the subject will complete at home (i.e., outside of the lab).
The oculomotor exercises will include saccadic eye movements performed in the horizontal and vertical planes.
All movements will be completed within a limited, comfortable range of motion with the head remaining stationary.
As the control intervention will be performed with the head stationary and in a seated position, no change in self-motion perception or balance is expected to result from the control (i.e., placebo) task.
|
Experimental: Training Protocol 4 - Placebo First
Participants will complete the training protocol that, after completion of preliminary basic science experiments, is found to most effectively reduce tilt thresholds AND improve balance in young adults.
The potential training stimulus parameters are as follows: (1) roll tilt, pitch tilt, LARP tilt, or RALP tilt motion, (2) stimulus size will be adjusted based upon subject responses using either a 2D/1U, 3D/1U, or 6D/1U staircase, and (3) either auditory, visual, or combined auditory+visual feedback will be provided.
The placebo intervention will be completed first, followed by the roll tilt training intervention.
|
The participants will be tilted and asked to indicate their perceived direction of self-motion (e.g., left or right).
Feedback will be provided to promote learning (i.e., improved perception of motion).
Feedback will only be provided after the subject response, and thus vestibular (i.e., self-motion) perception is required to judge the direction of the tilt stimulus.
After each trial, a 3 second period of rest will be given.
Each day of training will include three blocks of one-hundred trials each.
Testing will take place in the dark (except for aims where a visual cue is provided).
Subjects will be seated on a motion platform with a 5-point harness and the head restrained.
Noise cancelling earpieces (along with a white noise signal) will be used to reduce external noise.
Subjects will always be asked to make a decision (e.g.
left versus right) by pressing buttons with their left or right hands.
If not certain, subjects are instructed to provide their best guess.
Other Names:
The placebo (or control) task will consist of oculomotor exercises that the subject will complete at home (i.e., outside of the lab).
The oculomotor exercises will include saccadic eye movements performed in the horizontal and vertical planes.
All movements will be completed within a limited, comfortable range of motion with the head remaining stationary.
As the control intervention will be performed with the head stationary and in a seated position, no change in self-motion perception or balance is expected to result from the control (i.e., placebo) task.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Vestibular Roll Tilt Perceptual Thresholds
Time Frame: Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Vestibular perceptual thresholds will be measured using forced-choice methodologies; such methods have been used extensively.
Passive, whole body tilts will delivered using a Moog motion platform.
Subjects will be tilted in one of two directions (e.g., towards the left or right) in complete darkness and asked to report the perceive direction of motion.
All subjects will be seated in a chair with a 5-point harness.
The head will be restrained by a standard motorcycle helmet.
Noise cancelling headphones will be worn, reducing external noise by about 20 decibel (dB); to mask potential auditory directionality cues, auditory "noise" - uncorrelated with motion (amplitude, direction, or type) - will be applied at 60 dB sound pressure level (SPL).
Motion stimuli will consist of single cycles of sinusoidal acceleration.
using published methods.
|
Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Change in the Postural Sway During the Modified Romberg Balance Test
Time Frame: Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Static stance will be measured using a tri-axial force plate; postural sway will be measured in response to balance challenges including: (1) standing either on a foam or firm surface, (2) with the eyes either open or closed, and (3) with the feet together or in tandem.
The center of pressure (COP) root-mean-square-distance will serve as the primary outcome measure describing postural sway.
|
Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Change in Postural Sway during the Sensory Organization Test
Time Frame: Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
The Sensory Organization Test (SOT) is a standard clinical and research assessment used to quantify quiet stance postural sway in the presence of unreliable visual and proprioceptive feedback.
The conditions of the test include (1) eyes open firm surface, 2) eyes closed firm surface, 3) sway referenced vision firm surface, 4) eyes open sway referenced platform, 5) eyes closed sway referenced platform, 6) sway referenced visual surround and platform.
Sway-referencing describes a technique used to alter the reliability of proprioceptive and/or visual inputs by tilting the support surface or visual surround to follow the displacement of the CoP.
Center of pressure data will be collected in each condition using a tri-axial force plate; each condition will be repeated 3 times, for 20 seconds each.
The root mean square displacement of the center of pressure (CoP) will be calculated for each trial, using the median of 3 trials as the primary outcome.
|
Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in the Time to Failure During the Modified Romberg Balance Test
Time Frame: Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Static stance will be measured using a tri-axial force plate; postural sway will be measured in response to balance challenges including: (1) standing either on a foam or firm surface, (2) with the eyes either open or closed, and (3) with the feet together or in tandem.
If a trial cannot be completed due to a loss of balance, the time at which the loss of balance occurs will be recorded for each condition.
|
Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Change in Pass/Fail Performance on the Modified Romberg Balance Test
Time Frame: Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Static stance will be measured using a tri-axial force plate; postural sway will be measured in response to balance challenges including: (1) standing either on a foam or firm surface, (2) with the eyes either open or closed, and (3) with the feet together or in tandem.
The ability to complete the test (i.e., without a loss of balance) will be recorded.
|
Intervention First Group: Days 1, 6, 13, 36, 41; Placebo First Group: Days 1, 6, 11, 18, 41
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Daniel M Merfeld, PhD, Ohio State University
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- R01AG073113 (U.S. NIH Grant/Contract)
- 3R01AG073113-02S1 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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