- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01461395
Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm
August 23, 2012 updated by: University of South Florida
A Non-invasive Method to Assess DNA Damage in Individual Sperm
The purpose of this study is to find a non-invasive way to discover DNA (deoxyribonucleic acid, which is the genetic material inside your cells) alterations in the sperm's head, in the near future leading us to choose the "good sperm" in a simplified manner.
This could then increase chances of a successful in-vitro fertilization (IVF) treatment when there are sperm abnormalities.
Study Overview
Status
Completed
Detailed Description
If you take part in this study,
- Your physician is asking you to provide a semen sample as you already would. The sample will be taken to the IVF lab which would occur if you were not involved in this research. The part that would be thrown away is then further analyzed under a polarized light microscope. The sample is exposed to ultraviolet (UV) light for a period of 20 minutes after which it is analyzed under the microscope again, looking for any changes when compared the sample that was not exposed to UV light. The sample is then discarded.
- Your name will be removed from the sample after the regular semen analysis is done; therefore there will be no way of associating the research results with you. No information will be needed from you and you will not be contacted in the future regarding this research.
Study Type
Observational
Enrollment (Actual)
84
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Florida
-
Tampa, Florida, United States, 33606
- University of South Florida South Tampa Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 60 years (ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Male
Sampling Method
Non-Probability Sample
Study Population
IVF patients already undergoing therapy and providing a semen sample for sperm count
Description
Inclusion Criteria:
- Age 18-60 years
- provide informed consent
- Already providing a semen sample as routine therapy in IVF
Exclusion Criteria:
-unable to provide informed consent
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Celso Silva, M.D, University of South Florida
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2008
Primary Completion (ACTUAL)
June 1, 2012
Study Completion (ACTUAL)
June 1, 2012
Study Registration Dates
First Submitted
February 2, 2011
First Submitted That Met QC Criteria
October 27, 2011
First Posted (ESTIMATE)
October 28, 2011
Study Record Updates
Last Update Posted (ESTIMATE)
August 24, 2012
Last Update Submitted That Met QC Criteria
August 23, 2012
Last Verified
August 1, 2012
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 107209
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on DNA Damage
-
Bispebjerg HospitalSygehus LillebaeltActive, not recruitingDNA Damage | Ultraviolet Rays; Injury | DNA Adduct Formation | DNA Damage, Radiation InducedDenmark
-
University of ZagrebUniversity of Split, School of MedicineRecruiting
-
University of Split, School of MedicineRecruiting
-
Tahitian Noni International, Inc.University of Illinois at ChicagoCompletedDNA DamageUnited States
-
Tufts UniversityBASFCompleted
-
Muğla Sıtkı Koçman UniversityCompleted
-
Zeynep Kamil Maternity and Pediatric Research and...Not yet recruitingDNA Damage | Granulosa Cells
-
Ricard MarcosFinnish Institute of Occupational HealthRecruitingOccupational Exposure | Genotoxicity | Damage DnaFinland, Spain
-
McMaster UniversityNot yet recruitingOxidative Stress | Radiation Exposure | DNA Damage, Radiation Induced
-
University of British ColumbiaUnknownOxidative Stress | Sleep Quality | DNA Damage Repair Deficiency