Chronic Sleep Restriction (CSR)

Chronic Sleep Restriction: Neurobehavioral and Physiological Responses

Sleep is a physiological state considered essential for health and human survival. The prevalence of chronic sleep restriction has increased in modern society, as well as the effects of the same health concerns about various aspects, including the physiological and neurobehavioral. The objective of this study is to identify the neurobehavioral and physiological responses of healthy men with different needs of total sleep time (TST) submitted to chronic sleep restriction. Participants in this study will be 30 male volunteers, aged between 20 and 35 years, divided into three groups: Group 1 (n = 10) with TST ≤ 6 hours (h), Group 2 (n = 10) with TST ≥ 9h and Group 3 (n = 10): TST with between 7 and 8h. The TST will be established by the constant and continuous use of actigraphy for 10 days prior to the onset of the experimental protocol. All volunteers will undergo medical and polysomnography (PSG) examination to detect the presence or not of changes in sleep as well as other health problem that prevents their participation in the study. The experimental protocol consists of a basal night of sleep, five consecutive nights of chronic sleep restriction to 25% of TST in the beginning night and a night of recovery, which will be allowed to sleep the sleep pattern. Each night will have PSG monitoring and when wake up in each day, the volunteer will undergo tests to assess the physiological and neurobehavioral variables. The significance level will be 5% (p ≤ 0.05).

Study Overview

• Status: Completed
• Conditions: Other Conditions That May Be A Focus of Clinical Attention
• Intervention / Treatment: Other: Chronic Sleep Restriction

• Study Type: Observational
• Enrollment (Actual): 20

Contacts and Locations

Study Locations

• Brazil
  • SP
    • Sao Paulo, SP, Brazil, 04020-050
      • Federal University of São Paulo

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 35 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

• Sampling Method: Probability Sample

Study Population

Community sample, residents of Sao Paulo city

Description

Inclusion Criteria:

• Body Mass Index ≤ 25 kg/m2
• Physically active individuals
• 8 years of school education.

Exclusion Criteria:

• High level of anxiety - State-Trait Anxiety Inventory (STAI-T) ≥ 35
• High level of anxiety - Beck Depression Inventory ≥ 19
• PSQI - Pittsburgh Sleep Quality Index ≥ 11
• ESS - Epworth Sleepiness Scale ≥ 15
• Irregular rhythm of sleep identified by actigraphy
• Sleep disturbance by polysomnography
• Shift worker or nocturnal worker;
• Obesity;
• Smoker;
• Alcohol Intake of more than 3 drinks per day;
• Taking sleep medications or illicit drugs.

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group 1; Men with Total Sleep Time ≤ 6h that will undergo 25 percent of chronic sleep restriction of their TST	Other: Chronic Sleep Restriction; All volunteers will undergo 25% of sleep restriction of their total sleep time at the beginning sleep for five consecutive days. The nights will be monitored by polysomnography.; Other Names: Sleep; Chronic; Restriction
Group 2; Men with Total Sleep Time (range 7-8h)that will undergo 25 percent of chronic sleep restriction of their TST	Other: Chronic Sleep Restriction; All volunteers will undergo 25% of sleep restriction of their total sleep time at the beginning sleep for five consecutive days. The nights will be monitored by polysomnography.; Other Names: Sleep; Chronic; Restriction
Group 3; Men with Total Sleep Time ≥ 9h that will undergo 25 percent of chronic sleep restriction of their TST	Other: Chronic Sleep Restriction; All volunteers will undergo 25% of sleep restriction of their total sleep time at the beginning sleep for five consecutive days. The nights will be monitored by polysomnography.; Other Names: Sleep; Chronic; Restriction

Collaborators and Investigators

• Sponsor: Federal University of São Paulo
• Collaborators: Fundação de Amparo à Pesquisa do Estado de São Paulo; Associação Fundo de Incentivo à Pesquisa
• Investigators: Principal Investigator: Marco T De Mello, Ph.D, Federal University of São Paulo; Study Chair: Sergio Tufik, Ph.D, Federal University of São Paulo; Study Chair: Juliana MS Prado, Ph.D, Federal University of São Paulo; Study Chair: Patricia Rzezak, Ph.D, Federal University of São Paulo; Study Chair: Sandra S De Queiroz, Federal University of São Paulo

Publications and helpful links

Helpful Links

• Psychobiology department of Federal University of Sao Paulo
• Fundação de Amparo à Pesquisa do Estado de São Paulo

Study record dates

Study Major Dates

• Study Start: December 1, 2011
• Primary Completion (Actual): December 1, 2014
• Study Completion (Actual): February 1, 2015

Study Registration Dates

• First Submitted: December 14, 2011
• First Submitted That Met QC Criteria: December 15, 2011
• First Posted (Estimate): December 16, 2011

Study Record Updates

• Last Update Posted (Estimate): February 3, 2016
• Last Update Submitted That Met QC Criteria: February 2, 2016
• Last Verified: February 1, 2016

More Information

Terms related to this study

• Keywords: Sleep; Polysomnography; healthy; Sleep Deprivation; Reaction Time; Psychophysiology; Chronic sleep restriction; without sleep complaints
• Other Study ID Numbers: CEPE2011SSQueiroz