- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01561625
Signaling Pathway Activation After Exercise in Patients With Chronic Obstructive Pulmonary Disease (SIM)
Signaling Pathway Activation in the Quadriceps of Patients With COPD After an Acute Bout of Resistance
Muscle weakness and atrophy are important consequences of chronic obstructive pulmonary disease (COPD). Although resistance exercises increase strength and muscle mass in patients with COPD, the response to training appears to be suboptimal in these individuals. A dysregulation in the signaling pathways involved in the regulation of muscle mass could play an important role in this phenomenon.
Hypothesis: Proteins involved in muscle mass regulation will be less activated in the quadriceps of patients with COPD following the acute bout of resistance training exercise compared to healthy age-matched controls.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Quebec
-
Quebec City, Quebec, Canada, G1V 4G5
- IUCPQ
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Male
- COPD with an FEV1 of under 60% of predicted
- non-smoker
- Between 50 and 75 years old
Exclusion Criteria:
- All inflammatory disease (HIV, Cancer, renal and cardiac deficiency)
- Hormonal dysregulation
- Inferior limb pathology
- Neuromuscular pathology
- History of tabacco or alcool abuse
- Oxygen dependent
- Recent exacerbation (2 months) of the symptoms of COPD
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Post-exercise signaling proteins phosphorylation level in the quadriceps of COPD patients and age-matched healthy controls
Time Frame: 2 hours post-exercise
|
Phosphorylation status of key proteins (Akt, p70, mTOR, p38, JNK, ERK) will be lesser modulated in the quadriceps of patients with COPD compare to healthy controls.
The phosphorylated as well as the total protein levels will be measured by western blot.
The data will be presented as arbitrary units and compared with values obtained in healthy age-matched healthy controls.
|
2 hours post-exercise
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- SIM-COPD-20458
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