Co-infections in Children Hospitalised for Bronchiolitis

Co-infections in Children Hospitalised for Bronchiolitis: Incidence, Clinical Symptoms and Influence of Cohort Isolation

Observational cohort study in children hospitalized for acute bronchiolitis. Patients are nursed in cohort isolation. Aim is to investigate the incidence and clinical impact of co-infections in this group.

Study Overview

• Status: Completed
• Conditions: Bronchiolitis
• Intervention / Treatment: Other: cohort isolation

Detailed Description

Observational cohort study in children hospitalized for acute bronchiolitis. Patients are nursed in cohort isolation, meaning that all patients admitted for bronchiolitis are cohorted together, irrespective of viral diagnosis. Aim is to investigate the incidence and clinical impact of co-infections in this group.

• Study Type: Observational
• Enrollment (Actual): 172

Contacts and Locations

Study Locations

• Netherlands
  • Overijssel
    • Zwolle, Overijssel, Netherlands, 8000 GK
      • Isala Klinieken

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 6 months (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

children < 2 years admitted for bronchiolitis

Description

Inclusion Criteria:

• younger than 2 years admitted for bronchiolitis

Exclusion Criteria:

• chronic lung disease congenital heart defect down syndrome

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
cohort isolation; patients with bronchiolitis are cohorted together irrespective of viral agent diagnosed, thus respiratory syncytial virus (RSV)-positive patient stay in the same room as RSV-negative patients	Other: cohort isolation; all patients hospitalised for bronchiolitis are nursed in one room together, separated from patients without bronchiolitis

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
co-infection	co-infection acquired during hospitalisation, patient will be followed during hospitalisation and until 1 week after discharge from the hospital, since average duration of hospitalisation in infants with bronchiolitis is 3 days, the time frame will be approximately 2 weeks	approximately 2 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
clinical severity	clinical severity defined as, days of oxygen supplementation, tube feeding, dyspnea score, length of hospitalisation	approximately 2 weeks

Collaborators and Investigators

• Sponsor: Princess Amalia Children's Clinic
• Investigators: Principal Investigator: Jolita Bekhof, MD, Isala

Study record dates

Study Major Dates

• Study Start: November 1, 2012
• Primary Completion (Actual): May 1, 2015
• Study Completion (Actual): October 1, 2015

Study Registration Dates

• First Submitted: October 8, 2012
• First Submitted That Met QC Criteria: October 24, 2012
• First Posted (Estimate): October 25, 2012

Study Record Updates

• Last Update Posted (Estimate): October 22, 2015
• Last Update Submitted That Met QC Criteria: October 21, 2015
• Last Verified: October 1, 2015

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Lung Diseases; Bronchial Diseases; Lung Diseases, Obstructive; Bronchitis; Bronchiolitis; Coinfection
• Other Study ID Numbers: JB-3