The Effect of tDCS on Motor Performance and Cortical Excitability

February 24, 2014 updated by: Koen Cuypers, Hasselt University
In this study the effect of tDCS intensity on motor performance and corticospinal (CS) excitability is evaluated. The investigators expect that a positive relationship between current intensity and motor performance/CS excitability.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 85 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

- Healthy subjects

Exclusion Criteria:

  • Contraindications for tDCS/TMS
  • TMS measurements have to be possible

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Low intensity anodal tDCS
tDCS will be administered for 10 min at 1mA
Device: transcranial direct current stimulation (tDCS) (NeuroConn DC-stimulator)
The anode is fixed on the primary cortex and the cathode will be fixed on the contralateral supraorbital region.
Other Names:
  • NeuroConn DC-stimulator
Experimental: High intensity anodal tDCS
tDCS will be administered for 10 min at 2.5mA
Device: transcranial direct current stimulation (tDCS) (NeuroConn DC-stimulator)
The anode is fixed on the primary cortex and the cathode will be fixed on the contralateral supraorbital region.
Other Names:
  • NeuroConn DC-stimulator
Sham Comparator: Sham tDCS
Sham will be administered for 10 min at 0 mA
Device: transcranial direct current stimulation (tDCS) (NeuroConn DC-stimulator)
The anode is fixed on the primary cortex and the cathode will be fixed on the contralateral supraorbital region.
Other Names:
  • NeuroConn DC-stimulator

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in motor performance
Time Frame: Baseline and POST (30 min after baseline) intervention
motor performance is assessed using different reaction time paradigms (simple reaction time, choice reaction time). This is done at baseline and immediately after the intervention (30 min after baseline)
Baseline and POST (30 min after baseline) intervention
Change in cortical excitability
Time Frame: Baseline and POST (30 min after baseline) intervention
Cortical excitability is measured using trancranial magnetic stimulation (TMS) measuring muscle evoked potentials (MEPs) at baseline and POST (30 min after baseline).
Baseline and POST (30 min after baseline) intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hasselt University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2012

Primary Completion (Actual)

April 1, 2013

Study Completion (Actual)

June 1, 2013

Study Registration Dates

First Submitted

November 26, 2012

First Submitted That Met QC Criteria

November 30, 2012

First Posted (Estimate)

December 4, 2012

Study Record Updates

Last Update Posted (Estimate)

February 25, 2014

Last Update Submitted That Met QC Criteria

February 24, 2014

Last Verified

February 1, 2014

More Information

Terms related to this study

Other Study ID Numbers

  • MECU2012-004

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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