- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02157389
Psychobiological Mechanisms of Placebo and Nocebo Effects in the Treatment of Chronic Back Pain
January 15, 2015 updated by: Prof Herta Flor, Central Institute of Mental Health, Mannheim
Placebo and nocebo responses have mainly been studied in healthy humans for pharmacological rather than psychological interventions.
Moreover, only few studies examined patients or tested how previous experience and attitudes affect placebo and nocebo responses.
On the psychological level expectancy and classical conditioning have been identified as two primary mechanisms.
Both seem to be important with classical conditioning potentially having more long-term effects and expectancy being more important in nocebo effects.
There is some initial evidence from the investigators own research that patients may be more prone to these effects and the investigators have also shown that placebo effects may last up to several years after treatment.
The investigators therefore examine previous attitudes to pharmacological interventions for chronic pain in patients with chronic back pain and subdivide them into groups with high of low belief in the respective treatment modality.
The investigators then apply a pharmacological placebo and study the interaction between the prevailing attitude (implicit and explicit) and the placebo effect with respect to pain perception but also to neurobiological mechanisms using functional magnetic resonance imaging.
In addition to expectancy, conditioning of placebo will be examined and the long-term effects of the intervention will be determined.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
80
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Mannheim, Germany, 68159
- Central Institute of Mental Health
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Male and female human subjects with chronic back pain (chronic persistent and recurrent pain > 6 months)
- Age between 18 and 65
- Voluntary participation.
Exclusion Criteria:
- Acute or chronic somatic diseases and inflammatory, neuropathic or tumor-related pain
- Acute and chronic mental disorders according to DSM-IV (except for comorbid anxiety or depression, which are frequent in chronic pain)
- Insufficient German language skills
- Cognitive limitations
- Intake of opioid medication or tranquilizers
- Metal implants or electric implants that cannot be removed
- Pregnancy
- Claustrophobia
- History of epilepsy, brain trauma, or brain tumor
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: placebo
Administration of a pharmacological placebo (sodium chloride) via transdermal application to investigate the influence on pain perception in chronic back pain patients and to investigate the influence of attitude and experience with medication on the placebo effect
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes in pain intensity and pain unpleasantness ratings after placebo intervention
Time Frame: immediatey to one week
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immediatey to one week
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes in neuronal activity in response to painful stimulation after placebo administration
Time Frame: immediately
|
immediately
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Changes in movement abilities after placebo administration
Time Frame: immediately to one week
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immediately to one week
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2012
Primary Completion (Actual)
December 1, 2014
Study Completion (Actual)
December 1, 2014
Study Registration Dates
First Submitted
June 3, 2014
First Submitted That Met QC Criteria
June 5, 2014
First Posted (Estimate)
June 6, 2014
Study Record Updates
Last Update Posted (Estimate)
January 16, 2015
Last Update Submitted That Met QC Criteria
January 15, 2015
Last Verified
January 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Fl156/33-1_chrBP
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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