Hemodynamic Changes After Anesthesia With Propofol: Study of Biomarkers

August 25, 2016 updated by: Gustavo Henrique Oliveira de Paula, Conselho Nacional de Desenvolvimento Científico e Tecnológico
The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to propofol and the effects of these polymorphisms on biomarkers related to nitric oxide after propofol anesthesia. In addition, the investigators will evaluate the effects of propofol anesthesia on biomarkers related to nitric oxide in hypertensive patients chronically treated with angiotensin-converting enzyme inhibitors.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

65

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 80 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients under propofol anesthesia

Description

Inclusion Criteria:

  • ASA I or II
  • BMI lower 30 kg/m2

Exclusion Criteria:

  • Severe hypertension
  • Previous stroke
  • Previous infarction
  • Uncontrolled respiratory, renal, hepatic and hematological diseases.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Normotensive
Hypertensive taking ACEi
Hypertensive not taking ACEi

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Systolic blood pressure
Time Frame: 10 minutes
10 minutes
Diastolic blood pressure
Time Frame: 10 minutes
10 minutes
Mean blood pressure
Time Frame: 10 minutes
10 minutes
Heart rate
Time Frame: 10 minutes
10 minutes
Plasma nitrite levels
Time Frame: 10 minutes
10 minutes
Plasma nitrate levels
Time Frame: 10 minutes
10 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2015

Primary Completion (Actual)

December 1, 2015

Study Completion (Actual)

May 1, 2016

Study Registration Dates

First Submitted

May 7, 2015

First Submitted That Met QC Criteria

May 8, 2015

First Posted (Estimate)

May 13, 2015

Study Record Updates

Last Update Posted (Estimate)

August 26, 2016

Last Update Submitted That Met QC Criteria

August 25, 2016

Last Verified

August 1, 2016

More Information

Terms related to this study

Other Study ID Numbers

  • CNPq (Other Grant/Funding Number: CNPq480010/2007-2)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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