Frailty and Postoperative Outcomes After Emergency General Surgery

The investigators will examine the association between preoperative frailty and postoperative outcomes and resource utilization after emergency general surgery.

Study Overview

• Status: Completed
• Conditions: General Surgery; Geriatrics; Outcomes Research
• Intervention / Treatment: Other: Frailty

• Study Type: Observational
• Enrollment (Actual): 150000

Contacts and Locations

Study Locations

• Canada
  • Ontario
    • Ottawa, Ontario, Canada, K1Y 4E9
      • Ottawa Hospital Research Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All adult residents of Ontario with valid provincial health insurance who have an emergency general surgery procedure (large bowel surgery, small bowel surgery, cholecystectomy, control of hemorrhage from duodenal ulcer, lysis of adhesions, appendectomy, laparotomy)

Description

Inclusion Criteria:

• All residents of Ontario aged more than 65 years on their surgery date with valid provincial health insurance who have an emergency general surgery procedure (large bowel surgery, small bowel surgery, cholecystectomy, control of hemorrhage from duodenal ulcer, lysis of adhesions, appendectomy, laparotomy)

Exclusion Criteria:

• No valid provincial health insurance

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Emergency General Surgery; All patients having emergency general surgery procedures as defined by Scott et al (JAMA Surgery 2016)	Other: Frailty; Participants will be defined as frail based on the Johns Hopkins ACG Frailty Defining Diagnoses Indicator, which will be applied to available health administrative data in the 3 years preceding index hospital admission. If no frailty defining diagnoses are present participants will be defined as not frail

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality	Mortality events will be identified from the registered person's database in Ontario from the date of surgery to 365 days after surgery, at which time participants will be censored	365 days (from date of surgery)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hospital length of stay	Number of days in hospital from date of surgery to 365 days after surgery	day of surgery to 365 days after surgery
Intensive care unit admission	Presence of a special care unit admission from the Discharge abstract database from the date of surgery to 30 days after surgery	from date of surgery to 30 days after surgery
Institutional discharge	Discharge disposition to an institution in the discharge abstract database	Date of surgery to hospital discharge or 365 days after surgery (at which time participants will be censored)
Costs	Total costs incurred by the provincial health care system from the day of surgery to 365 days after surgery	day of surgery to 365 days after surgery

Collaborators and Investigators

• Sponsor: Ottawa Hospital Research Institute

Study record dates

Study Major Dates

• Study Start: April 1, 2002
• Primary Completion (Actual): March 1, 2014
• Study Completion (Actual): March 1, 2014

Study Registration Dates

• First Submitted: July 13, 2016
• First Submitted That Met QC Criteria: July 14, 2016
• First Posted (Estimate): July 15, 2016

Study Record Updates

• Last Update Posted (Estimate): July 15, 2016
• Last Update Submitted That Met QC Criteria: July 14, 2016
• Last Verified: July 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Emergencies; Frailty
• Other Study ID Numbers: DM3

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED