- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02836145
Biomolecular Messages Associated With the Differentiation of Human Induced Pluripotent Stem Cells to Skeletal Muscle Progenitor Cells
Female urinary incontinence and pelvic organ prolapse are common diseases especially in aged women that frequently cause urogenital infection, voiding difficulty, urinary retention, pelvic pain, constipation, and coital difficulty, as well as impact the quality of life of women. Risk factors of the above diseases include pregnancy, vaginal delivery, and menopausal status. Despite playing a crucial role in the pathophysiology of the above diseases, the urogenital skeletal muscular dysfunction cannot be fully corrected via the current treatment modalities.
The human induced pluripotent stem cells (hiPSCs) represent a prime candidate cell type for current research and future cell therapy because of their significant self-renewal, differentiation potential and the relative lack of ethical conflict. With the advent of efficient technology of reprogramming peripheral blood mononuclear cells (PBMCs) into hiPSCs, researchers can generate personalized lines of cells from which it will be possible to obtain differentiated cells in a less invasive way, introducing opportunities in treating diseases that are now considered incurable.
Until very recently, little success has been achieved in terms of skeletal muscle differentiation from hiPSCs. The purpose of this study is to explore the applicability of the differentiation into skeletal muscle progenitor cells from hiPSC cell lines and the associated biomolecular messages. It is anticipated that the derived skeletal muscle progenitor cells can be reprogrammed from PBMCs of female patients with urinary incontinence and/or pelvic organ prolapse and used in preclinical testing for relieving female urogenital problems.
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- human induced pluripotent stem cells, hiPSCs
Exclusion Criteria:
-
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Cell count
Time Frame: Day 50
|
Day 50
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NTU-REC-201603059RINA
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Clinical Trials on Female Urinary Incontinence and Pelvic Organ Prolapse
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Giresun UniversityActive, not recruitingPelvic Organ Prolapse | IncontinenceTurkey
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ASTORA Women's HealthTerminatedPelvic Organ Prolapse | Female Stress IncontinenceUnited States, Spain, Slovenia, France, United Kingdom, Canada, Germany, South Africa
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Mackay Memorial HospitalRecruitingPelvic Organ Prolapse | IncontinenceTaiwan
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Loyola UniversityCompletedPelvic Organ Prolapse | Stress Urinary Incontinence | Urge IncontinenceUnited States
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Taipei Veterans General Hospital, TaiwanRecruitingPelvic Organ Prolapse | Stress Urinary Incontinence | Pelvic Floor DisordersTaiwan
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The Methodist Hospital Research InstituteCompletedPelvic Organ Prolapse | Stress Urinary Incontinence | Pelvic Floor DisordersUnited States
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National Taiwan University HospitalActive, not recruitingProlapse; FemaleTaiwan
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University of VirginiaRecruiting
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University of South FloridaCompletedPelvic Organ Prolapse | Stress Urinary IncontinenceUnited States
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International Urogynecological SocietyCompletedSexual Dysfunction | Pelvic Organ Prolapse | Pelvic Floor Disorders | IncontinenceUnited States, United Kingdom
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