LearningRx Cognitive Training for Brain Injury

February 11, 2026 updated by: Gibson Institute of Cognitive Research

LearningRx Cognitive Training for Traumatic Brain Injury (TBI) and Acquired Brain Injury (ABI)

The purpose of this investigation is to conduct a series of case studies on the impact of LearningRx cognitive training on cognitive skills, daily functioning, and workplace self-efficacy for participants with Traumatic Brain Injury (TBI) /Acquired Brain Injury (ABI).

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

The proposed study will examine the outcomes from LearningRx one-on-one cognitive training across domains on standardized measures and qualitative measures used to monitor treatment effectiveness for brain injury.

Study Type

Interventional

Enrollment (Estimated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Colorado
      • Colorado Springs, Colorado, United States, 80919
        • Gibson Institute of Cognitive Research

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 60 years (Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

- Age 18+ previously diagnosed with TBI/ABI

Exclusion Criteria:

  • No braces, metal implants, or claustrophobia that would contraindicate magnetic resonance imaging for participants receiving MRI only

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: LearningRx cognitive training
The intervention is a 60-90 hour, clinician-delivered cognitive training program.
Behavioral: LearningRx cognitive training
A clinician will deliver three 90-minute cognitive training sessions per week for 14 weeks. There are 16 different categories of leveled training procedures sequenced in intensity and difficulty for a total of 530 training tasks. Participants will receive training in-person or remotely depending on state of residence.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Evidence of Change in Workplace Self-Efficacy
Time Frame: Baseline and 9 months
Confirmed by change on 29-item Workplace Self-Efficacy Survey
Baseline and 9 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Evidence of overall cognitive function improvement
Time Frame: Baseline and 9 months
Confirmed by change in pretest to post-test scores on the Woodcock Johnson IV - Tests of Cognitive Abilities
Baseline and 9 months
Evidence of Change in Self-Reported Functioning at Home and Work
Time Frame: Baseline and 9 months
Confirmed by qualitative interview of pre-intervention symptoms and functioning and post-intervention symptoms and functioning
Baseline and 9 months
Evidence of reduction in TBI symptoms
Time Frame: Baseline and 9 months
As confirmed by pretest to post-test changes on the Traumatic Brain Injury Checklist (Note: for TBI participants only)
Baseline and 9 months
Evidence of change in brain activity
Time Frame: Baseline and 9 months
As confirmed by pretest to post-test changes in electrical activity measured by qEEG. (Note: for TBI in-person participants only; not for remote participants)
Baseline and 9 months
Evidence of change in brain structure
Time Frame: Baseline and 9 months
Confirmed by change in pretest to post-test neuroimaging using MRI. (Note: for in-person TBI participants only; not for remote participants.)
Baseline and 9 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Gibson Institute of Cognitive Research

Collaborators

Louisiana State University Health Sciences Center Shreveport

Investigators

  • Study Director: Amy L Moore, PhD, Gibson Institute of Cognitive Research
  • Principal Investigator: Christina Ledbetter, PhD, Gibson Institute of Cognitive Research and LSU Health Shreveport

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2016

Primary Completion (Actual)

September 1, 2025

Study Completion (Estimated)

December 1, 2027

Study Registration Dates

First Submitted

September 27, 2016

First Submitted That Met QC Criteria

September 27, 2016

First Posted (Estimated)

September 29, 2016

Study Record Updates

Last Update Posted (Actual)

February 13, 2026

Last Update Submitted That Met QC Criteria

February 11, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • GICR-0916-B

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Will add to Harvard Dataverse

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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