- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02030366
Chromatic Multifocal Pupillometer for Detection and Follow-up of Acute Head Injury
A Portable Chromatic Multifocal Pupillometer for Objective Early Detection and Follow-up of Changes in Intracranial Pressure in Patients With Acute Head Injury
Study Overview
Status
Conditions
Detailed Description
To examine the feasibility of using the multifocal chromatic pupillometer for monitoring TBI, the pupillary response to multifocal chromatic stimuli will be assessed in 20 healthy subjects and 20 ICP-monitored severe TBI patients.
The portable pupillometer will be tested in 20 healthy volunteers. Their pupillary responses will be measured 3 times/day for 1 week.
Pupillary response of 20 severe TBI patients will be evaluated as detailed below at the following time points:
- At admittance to ICU, prior to insertion of ICP and CT scan
- Prior to CT scans that are routinely performed at day 3 and 7 post injury
- Routinely at the beginning of every medical personnel shift for 7 days (3 times a day).
- With every change in ICP(more than 5 mmHg for more then 15 min) Data will be recorded and analyzed.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Jacob Zauberman, MD
- Phone Number: 97235302440
- Email: Jacob.Zauberman@sheba.health.gov.il
Study Contact Backup
- Name: Ygal Rotenstreich, MD
- Phone Number: 97235302880
- Email: Ygal.Rotenstreich@sheba.health.gov.il
Study Locations
-
-
-
Tel Hashomer, Israel, 52621
- Recruiting
- Neurosurgery Department, Sheba Medical Center
-
Contact:
- Jacob Zauberman, MD
- Phone Number: 97235302440
- Email: Jacob.Zauberman@sheba.health.gov.il
-
Contact:
- Lori Gueta
- Phone Number: 97235308132
- Email: Lori.Gueta@sheba.health.gov.il
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Healthy subjects -
- Male or female patients, age between 18 and 70 years, inclusive
- Informed written consent will be obtained from all participants.
- Normal eye examination
- Best-corrected visual acuity (BCVA) of 20/20
- Normal color vision test (Roth-28-hue test)
- Written informed consent to participate in the study,
- TBI-patients:
- Male or female patients, age between 18 and 70 years, inclusive
- Initiation of study before the insertion of the ICP monitor.
- TBI diagnosed by history and clinical examination
- Glasgow Coma Scale (GCS) score between 3 and 8, inclusive
- Evidence of TBI confirmed by abnormalities consistent with trauma on CT scan upon admission (diffuse injury II-IV, evacuated and non-evacuated mass lesion, Marshall's CT Classification)
- Indication for ICP monitoring
- Written informed consent to participate in the study, signed by a family member and independent physician.
Exclusion Criteria:
- Healthy subjects
- History of past or present ocular disease
- Use of any topical or systemic medications that could adversely influence efferent pupil movements
- TBI-patients
- High levels of barbiturate medications as they abolish pupillary responsiveness
- Coma suspected to be primarily due to other causes (e.g. alcohol)
- Preexisting clinically significant disease or chronic condition that can be ascertained at the time of admission and could affect pupillary response or measurement (such as known retinal dystrophy disease, glaucoma or dense cataract.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
---|
Healthy Volunteers
|
TBI patients
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pupillary response at 5 points of Visual field to blue and red light
Time Frame: 7 days
|
Pupillary response at 5 points of Visual field to blue and red light will be measured 3 times a day for a week for the health subjects. The TBI patients will be monitored for pupillary response:
|
7 days
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Intra Cranial Pressure
Time Frame: 7 days
|
TBI patients only will be continuously monitored for Intra Cranial Pressure (ICP)
|
7 days
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 9994-12-SMC
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Traumatic Brain Injury (TBI) Patients
-
University of Texas Southwestern Medical CenterHackensack Meridian Health; Kessler Institute for Rehabilitation; Baylor Health...CompletedCare Partners of Patients With Traumatic Brain Injury (TBI)United States
-
ElMindA LtdAthletico Physical TherapyCompletedMinor Traumatic Brain Injury (TBI)United States
-
ElMindA LtdNoran Neurological ClinicCompletedHealthy | Minor Traumatic Brain Injury (TBI)United States
-
ElMindA LtdYork UniversityCompletedMinor Traumatic Brain Injury (TBI)Canada
-
University of MinnesotaNot yet recruitingTBI (Traumatic Brain Injury)United States
-
Kent State UniversityVirginia Commonwealth UniversityRecruitingTBI (Traumatic Brain Injury)United States
-
Pomeranian Medical University SzczecinCompletedTBI (Traumatic Brain Injury)Poland
-
San Francisco Veterans Affairs Medical CenterVA Office of Research and DevelopmentCompletedTBI (Traumatic Brain Injury)United States
-
University of HelsinkiHelsinki University Central Hospital; University of Virginia; University of Jyvaskyla and other collaboratorsCompletedTraumatic Brain Injury (TBI)Finland
-
University of TurkuTurku University Hospital; The Finnish Funding Agency for Technology and Innovation... and other collaboratorsCompletedBrain Injuries | TBI (Traumatic Brain Injury) | Brain Injuries, Traumatic | Traumatic Brain Injury | Injury, Brain, TraumaticFinland