Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography

The study investigates the influence of a clinically indicated fluid challenge on end-expiratory lung impedance, assessed by electrical impedance tomography (EIT). EIT data will be collected before, during and after infusion of 500 ml of crystalloid solution in mechanically ventilated patients on an operative intensive care unit.

Study Overview

• Status: Completed
• Conditions: Respiratory Failure; Fluid Overload; Circulatory Failure; Fluid Responsiveness
• Intervention / Treatment: Other: Fluid Challenge

• Study Type: Observational
• Enrollment (Actual): 25

Contacts and Locations

Study Locations

• Germany
  • Schleswig-Holstein
    • Kiel, Schleswig-Holstein, Germany, 24145
      • University Medical Center Schleswig Holstein, Campus Kiel

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Mixed population of intensive care unit patients

Description

Inclusion Criteria:

• patients on mechanical ventilation
• clincial decision to monitor regional ventilation with electrical impedance tomography
• clinical indication for fluid challenge
• established cardiac output monitoring with transpulmonary thermodilution

Exclusion Criteria:

• age < 18 years
• open lung injuries
• instable injury of spine or cranium
• thoracic metal implants
• body mass index > 35

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in end-expiratory lung impedance (EELI)	To assess the effect of fluid challenge on EELI, the change in EELI during the fluid challenge will be measured by electrical impedance tomography and will be compared to the change in EELI during the last 15 minutes before start of the fluid challenge.	15-30 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation between change in end-expiratory lung impedance and change in intrathoracic blood volume	We will assess the correlation between the change in end-expiratory lung impedance during infusion of 500 ml of crystalloid solution and the change in intrathoracic blood volume (assessed by transpulmonary thermodilution) during the same time period.	15-30 minutes
Fluid responsiveness	We will investigate whether the ratio of cardiac-related impedance changes to ventilation-related impedance changes, measured by EIT at baseline (i.e. before start of fluid challenge), can predict fluid responsiveness, defined as an increase in stroke volume of greater or equal to 15% compared to baseline.	15-30 minutes

Collaborators and Investigators

• Sponsor: University Hospital Schleswig-Holstein

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2016
• Primary Completion (Actual): December 1, 2017
• Study Completion (Actual): December 1, 2017

Study Registration Dates

• First Submitted: December 9, 2016
• First Submitted That Met QC Criteria: December 9, 2016
• First Posted (Estimate): December 14, 2016

Study Record Updates

• Last Update Posted (Actual): May 3, 2018
• Last Update Submitted That Met QC Criteria: May 2, 2018
• Last Verified: May 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Respiratory Tract Diseases; Respiration Disorders; Respiratory Insufficiency; Shock
• Other Study ID Numbers: EIT Fluid Challenge

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO