The Effects of a Train High, Sleep Low Strategy

The Effects of a Train High, Sleep Low Strategy on Performance, Substrate Utilization and Muscular Adaptations in Moderately Trained Cyclists

The investigators will examine the long-term effects of a combined training and diet intervention that, acutely, increases fat oxidation during exercise. This is done with a 4 week intervention study with moderately trained cyclists. Performance is tested pre and post intervention and muscle biopsies are obtained.

Study Overview

• Status: Completed
• Conditions: Substrate Utilization; Cycling Performance; Muscular Adaptations
• Intervention / Treatment: Other: Combined exercise and diet intervention

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• 18-45 years
• VO2-max>55 ml/kg/min
• No smokers
• Training 6 hours per week (cycling)
• Training experience for more than 3 years.

Exclusion Criteria:

• Less than 2 g carbohydrate/kg/day

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Low group; This subjects in this group conducts all their morning exercise sessions with high fat oxidation (in a fasted condition). Thus, the subjects in this group after high intensity exercise in the evening do not get any carbohydrates to eat after training until the exercise session the following morning has been conducted.	Other: Combined exercise and diet intervention; Both groups exercise 6 times per week in 4 weeks conducted as 3 evening and 3 morning sessions per week. Both groups receive dietary products to be consumed immediately before and after each evening and morning session, respectively. One group conduct morning sessions in a fasted state, the other conduct the morning sessions in a fed state. Performance pre and post is measured, and muscle biopsies are obtained.
Active Comparator: High group; This subjects in this group conducts all their morning exercise sessions with low fat oxidation (in a fed condition). Thus, the subjects in this group after high intensity exercise in the evening do get carbohydrates to eat after training until the exercise session the following morning has been conducted.	Other: Combined exercise and diet intervention; Both groups exercise 6 times per week in 4 weeks conducted as 3 evening and 3 morning sessions per week. Both groups receive dietary products to be consumed immediately before and after each evening and morning session, respectively. One group conduct morning sessions in a fasted state, the other conduct the morning sessions in a fed state. Performance pre and post is measured, and muscle biopsies are obtained.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time trial performance measured in Watts	30 min time trial after 90 minutes of intensive cycling. The average amount of Watts during the 30 minutes will be measured.	Change from Baseline and after 4 weeks of training

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Protein expression in skeletal muscle tissue	Amount of mitochondrial proteins and enzymes will be measured with a Western Blotting technique	Baseline and after 4 weeks of training
The absolute amount of carbohydrate and fat which is metabolised during morning exercise, measured in grams/minute	Fat and carbohydrate oxidation during exercise measured and estimated with indirect calorimetry.	Baseline and after 4 weeks of training

Collaborators and Investigators

• Sponsor: University of Aarhus
• Collaborators: Team Denmark

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2016
• Primary Completion (Actual): December 20, 2016
• Study Completion (Actual): October 10, 2018

Study Registration Dates

• First Submitted: January 29, 2017
• First Submitted That Met QC Criteria: February 6, 2017
• First Posted (Estimate): February 7, 2017

Study Record Updates

• Last Update Posted (Actual): October 24, 2018
• Last Update Submitted That Met QC Criteria: October 23, 2018
• Last Verified: October 1, 2018

More Information

Terms related to this study

• Other Study ID Numbers: Sleep low

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No