Dexmedetomidine Infusion as an Analgesic Adjuvant During Laparoscopic Cholecystectomy

Dexmedetomidine Infusion as an Analgesic Adjuvant During Laparoscopic Cholecystectomy: Randomized Controlled Study

The aim of this study was to evaluate efficacy and safety of dexmedetomidine infusion during laparoscopic cholecystectomy. The randomized, single-center, controlled study was carried out from May 2016 to June 2017 at department of surgery, anesthesiology and intensive care, Postgraduate Institute of Bogomolets National Medical University.

Study Overview

• Status: Unknown
• Conditions: Pain, Postoperative
• Intervention / Treatment: Drug: Dexmedetomidine; Drug: Normal Saline Flush, 0.9% Injectable Solution_#1

Detailed Description

Dexmedetomidine provide sedative, sympatholytic and analgesic effect, so it could be used as an adjuvant to improve analgesia, hemodynamic response to intubation and pneumoperitoneum, decrease the number of opioid-associated adverse effects.

The aim of this study was to evaluate efficacy and safety of dexmedetomidine infusion during laparoscopic cholecystectomy.

The randomized, single-center, controlled study was carried out from May 2016 to June 2017 at department of surgery, anesthesiology and intensive care, Postgraduate Institute of Bogomolets National Medical University. Study design was approved by Ethical Committee at Bogomolets National Medical University (approval code 56).

60 patients elected for LCE were included in the study. The inclusion criteria were: age between 18 and 79 years, either sex, American Society of Anesthesiology (ASA) physical status I to II. The exclusion criteria were age outside the specified range, pregnancy or lactation, severe systemic disease (ASA III physical status), patients on b-blockers or calcium channel blockers.

After the primary patient assessment, eligible participants were assigned in a 1:1 ratio to either the intervention (Group D) or control (Group C) groups using random assignment in blocks of four. The randomization sequence was generated using a computer algorithm [19]. Randomization and data analysis were conducted by an independent blinded member of the research team.

Group D received dexmedetomidine infusion 0,5 mcg/kg/h from induction in anesthesia to extubation, group C (control) received normal saline infusion. To prepare the infusion, dexmedetomidine 2ml containing 100mcg of the drug was diluted up to 50 ml with normal saline resulting in final concentration of 4mcg/kg. Dexmedetomidine or normal saline infusion was given through infusion pump.

After taking the patient to the operation room, vital signs monitor Philips and Bispectral Index (BIS) monitoring were attached (pulse, heart rate, electrocardiography (ECG), arterial pressure (AP), oxygen saturation). Peripheral intravenous cannula was inserted for intravenous fluids and infusion pump (separate line). Patients did not receive premedication. Before induction they receive dexketoprofen 50mg IV and omeprazole 40mg.

Pre-oxygenation was performed for 2 min, induction in anesthesia - with propofol 2mg/kg IV and succinyl choline 1,5mg/kg IV. After intubation anesthesia was maintained with sevoflurane and atracurium bromide. The patients were ventilated with circle system with goal CO2 35-45 mm Hg. BIS-monitor target was between 40 and 60. Anesthetics and drug infusion were stopped with the end of surgery.

The primary efficacy outcomes were number of patients with severe pain, time to first rescue analgesia and postoperative morphine consumption. Severe pain was estimated as VAS≥7 during 30% or more time in first 48 hours after surgery. Time to first rescue analgesia was estimated as time from end of anesthesia to the time postoperatively when patient ask for analgesia or have VAS≥4. Injection morphine hydrochlorides 10mg subcutaneously was used as a rescue analgesic. NSAIDs (dexketoprofen 150mg per day) were prescribed routinely.

Secondary efficacy outcomes included:

• Time from end of surgery to extubation
• Lengths of postanesthesia unit/general ward stay
• Incidence of chronic postoperative pain During first 48 hours after surgery patients in both groups were evaluated by the nursing stuff using the Richmond agitation sedation scale (RASS) for sedation, visual analogue scale (VAS) for pain assessment (every 2 hours or prior to rescue analgesia).

Safety was assessed by monitoring vital signs and recording adverse events. During anesthesia all patients receive continuous ECG, BIS, pulse oximetry, capnography monitoring. AP was measured every 3-5min. Arterial blood gases were checked by doctor prescription. An adverse event was recorded if systolic blood pressure was <90 or >160 mmHg or if heart rate was <50 or >110 beats/min; desaturation was estimated as peripheral oxygen saturation (or SaO2) <90%. Interventions for bradycardia, tachycardia, hypertension and hypotension comprised titration or interruption of study agent, or additional drug therapy.

Statistical analysis was performed using R software. Categorical data are presented as proportions and continuous data as medians with 25-75% interquartile ranges (IQRs). Chi-square testing demonstrated that all of the study variables were discrete. To assess significance levels, a two-tailed Mann-Whitney U-test and Fisher's exact test were used. A p-value of <0.05 was considered significant.

• Study Type: Interventional
• Enrollment (Anticipated): 60
• Phase: Phase 3

Contacts and Locations

Study Locations

• Ukraine
  • Kyiv, Ukraine, 02140
    • Recruiting
    • Kyiv Clinical City Hospital #1
    • Contact: Iurii Kuchyn, Prof; Phone Number: 380677275825; Email: kuchyn2@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 79 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• patients elected for laparoscopic cholecystectomy
• age between 18 and 79 years
• either sex
• ASA physical status I to II

Exclusion Criteria:

• age outside the specified range
• pregnancy or lactation
• severe systemic disease (ASA III physical status or more)
• patients on b-blockers or calcium channel blockers

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Group D; Group D received dexmedetomidine infusion 0,5 mcg/kg/h from induction in anesthesia to extubation	Drug: Dexmedetomidine; Intraoperative intravenous dexmedetomidine infusion 0,5 mcg/kg/h
Placebo Comparator: Croup C; group C (control) received normal saline infusion	Drug: Normal Saline Flush, 0.9% Injectable Solution_#1; Intraoperative intravenous normal saline infusion

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
number of patients with severe pain	number of patients with severe pain estimated as VAS≥7 during 30% or more time in first 48 hours after surgery	48 hours after surgery
Time to first rescue analgesia	time from end of anesthesia to the time postoperatively when patient ask for analgesia or have VAS≥4	24 hours after surgery
morphine consumption	total morphine consumption after surgery in mg	48 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time of extubation	Time from end of surgery to extubation	24 hours after surgery
Incidence of chronic postoperative pain	number of patients with chronic postoperative pain	6 month after surgery

Collaborators and Investigators

• Sponsor: Bogomolets National Medical University

Publications and helpful links

General Publications

• Bielka K, Kuchyn I, Babych V, Martycshenko K, Inozemtsev O. Dexmedetomidine infusion as an analgesic adjuvant during laparoscopic small es, Cyrillicholecystectomy: a randomized controlled study. BMC Anesthesiol. 2018 Apr 20;18(1):44. doi: 10.1186/s12871-018-0508-6.

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2016
• Primary Completion (Anticipated): August 1, 2017
• Study Completion (Anticipated): October 1, 2017

Study Registration Dates

• First Submitted: July 4, 2017
• First Submitted That Met QC Criteria: July 6, 2017
• First Posted (Actual): July 7, 2017

Study Record Updates

• Last Update Posted (Actual): July 7, 2017
• Last Update Submitted That Met QC Criteria: July 6, 2017
• Last Verified: July 1, 2017

More Information

Terms related to this study

• Keywords: pain management, dexmedetomidine
• Additional Relevant MeSH Terms: Pathologic Processes; Postoperative Complications; Pain; Neurologic Manifestations; Pain, Postoperative; Physiological Effects of Drugs; Adrenergic Agents; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Central Nervous System Depressants; Peripheral Nervous System Agents; Analgesics; Sensory System Agents; Analgesics, Non-Narcotic; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic Agonists; Hypnotics and Sedatives; Dexmedetomidine
• Other Study ID Numbers: 87678

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided
• IPD Plan Description: IPD will not be available

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No